Rivera J, Hill N C, López Bernal A, Mackenzie I Z, Cano A
Department of Obstetrics and Gynaecology, Facultad de Medicina, Universidad de Valencia, Spain.
Hum Reprod. 1991 Oct;6(9):1338-41. doi: 10.1093/oxfordjournals.humrep.a137536.
P29 is an oestrogen receptor-associated protein which acts as a marker of oestrogen action in several systems. The concentration of P29 was measured in placenta and decidua from women following medical termination of pregnancy with the antiprogesterone steroid mifepristone (RU 38,486) and a prostaglandin E1 analogue, and compared with the concentration of P29 found in matched controls undergoing surgical aspiration of pregnancy. Oestrogen receptors were also measured in the same samples. Placental and decidual P29 concentrations (IU/mg protein) in patients treated with mifepristone were 9.6 (4.6-54) and 4.8 (1.3-13.3) (median and range), respectively. These values were significantly lower than the corresponding values, 39.5 (27-69) and 22.0 (2-107) in the surgical group. In contrast, the levels of oestrogen receptors did not change significantly in either decidua or placenta. These data show that mifepristone causes down-regulation of P29 in placenta and decidua, and therefore its action may disrupt oestrogen function in uterine tissues.
P29是一种雌激素受体相关蛋白，在多个系统中作为雌激素作用的标志物。在使用抗孕激素类固醇米非司酮（RU 38,486）和前列腺素E1类似物进行药物流产的女性的胎盘和蜕膜中测量P29的浓度，并与接受手术吸宫流产的匹配对照组中发现的P29浓度进行比较。同时也在相同样本中测量雌激素受体。接受米非司酮治疗的患者胎盘和蜕膜中的P29浓度（IU/mg蛋白）分别为9.6（4.6 - 54）和4.8（1.3 - 13.3）（中位数和范围）。这些值显著低于手术组相应的值39.5（27 - 69）和22.0（2 - 107）。相比之下，蜕膜或胎盘中雌激素受体水平在两组中均无显著变化。这些数据表明米非司酮导致胎盘和蜕膜中P29下调，因此其作用可能会破坏子宫组织中的雌激素功能。
