Hill N C, Rivera J, Lopez Bernal A, MacKenzie I Z
Nuffield Department of Obstetrics & Gynaecology, University of Oxford, John Radcliffe Hospital, Headington, UK.
Hum Reprod. 1990 May;5(4):464-7. doi: 10.1093/oxfordjournals.humrep.a137124.
Decidual and placental concentrations of progesterone and oestrogen receptors in 15 women having medical terminations of pregnancy with a combination of the anti-progesterone steroid RU 38,486 and prostaglandin E1 analogue have been compared with 10 matched controls undergoing surgical aspiration of pregnancy. In the patients treated with RU 38,486, the mean (SD) decidual cytosolic and total progesterone receptor concentrations of 4.3 (5.6) and 7.6 (7.1) fmol/microgram DNA respectively were significantly lower than the levels of 18.5 (14.4) and 22.3 (17.4) fmol/microgram DNA in the control patients. Progesterone receptor concentrations in the placenta were very low in both groups. No significant change in oestrogen receptor concentrations occurred in the decidua or placenta after treatment with RU 38,486. These data indicate that there may be down-regulation of decidual progesterone receptor concentrations following RU 38,486 treatment.
将15名使用抗孕酮类固醇RU 38,486和前列腺素E1类似物联合进行中期妊娠药物流产的女性的蜕膜和胎盘组织中孕酮和雌激素受体浓度，与10名接受手术吸宫流产的匹配对照者进行了比较。在接受RU 38,486治疗的患者中，蜕膜胞浆和总孕酮受体浓度平均（标准差）分别为4.3（5.6）和7.6（7.1）fmol/微克DNA，显著低于对照患者的18.5（14.4）和22.3（17.4）fmol/微克DNA水平。两组胎盘组织中的孕酮受体浓度都非常低。用RU 38,486治疗后，蜕膜或胎盘组织中的雌激素受体浓度没有显著变化。这些数据表明，RU 38,486治疗后蜕膜孕酮受体浓度可能会下调。
