Zaytseva T S, Goncharova V N, Morozova M S, Astakhova T M, Manuilova I A, Pankov Y A
Endocrine Research Centre AMS of Russia, Moscow.
Hum Reprod. 1993 Aug;8(8):1288-92. doi: 10.1093/oxfordjournals.humrep.a138243.
Concentrations of progesterone receptor (PR) and oestrogen receptor (ER) were measured by radioligand assay in decidual tissue of women undergoing termination of early pregnancy (amenorrhoea up to 49 days). Pregnancies were terminated by vacuum aspiration at 12 or 36 h after oral administration of placebo or antiprogestin RU486 in different doses. Treatment with RU486 decreased decidual PR content, the effect being observed at 12 h as well as at 36 h after 600 mg RU486 and at 36 h after 3 x 25 mg RU486 given at 12 h intervals. PR concentration 12 h after a single dose of 25 mg RU486 was not affected. ER content was unchanged at 12 h after RU486 but increased 36 h after 600 mg and 3 x 25 mg RU486. Our data suggest that apart from blocking progesterone action, RU486 may exert its abortifacient effect through decreasing the PR concentration. The simultaneous decrease of PR concentration and an increase of ER concentration changes the balance between them in favour of ER, which might also play a role in the abortifacient effect of RU486.
通过放射性配体分析法测定了早期妊娠终止（闭经49天以内）妇女蜕膜组织中孕酮受体（PR）和雌激素受体（ER）的浓度。在口服不同剂量的安慰剂或抗孕激素RU486后12或36小时，通过真空吸引术终止妊娠。用RU486治疗可降低蜕膜PR含量，在给予600mg RU486后12小时和36小时以及每隔12小时给予3×25mg RU486后36小时均观察到这种效果。单次给予25mg RU486后12小时的PR浓度未受影响。RU486给药后12小时ER含量未改变，但在给予600mg和3×25mg RU486后36小时增加。我们的数据表明，除了阻断孕酮作用外，RU486可能通过降低PR浓度发挥其堕胎作用。PR浓度的同时降低和ER浓度的增加改变了它们之间有利于ER的平衡，这也可能在RU486的堕胎作用中起作用。
