Caswell M, Stuart J
Department of Haematology, Medical School, University of Birmingham.
J Clin Pathol. 1991 Nov;44(11):946-9. doi: 10.1136/jcp.44.11.946.
Measurement of the erythrocyte sedimentation rate (ESR) using a closed tube system reduces the biohazard risk to laboratory staff. The Diesse Ves-matic system offers manual or vacuum collection of blood into plastic tubes, automated mixing of the sample, and automated reading of the end point after 20 minutes of sedimentation. This system was compared with the 1977 Westergren ESR method of the International Council for Standardization in Haematology (ICSH) and with the 1988 ICSH undiluted ESR method. Manually collected Ves-matic samples showed good agreement with ICSH values, although there was a tendency to false low results at low ESR values which may represent dilution of plasma protein with excess citrate. Vacuum collected Ves-matic samples also showed good agreement with ICSH values, although there was a tendency to false high results which may reflect a change in the blood: citrate ratio caused by loss of anticoagulant diluent or vacuum from plastic tubes during storage. The Diesse Ves-matic system incorporates several improvements over previous technology and offers a safer, quicker, and more standardised ESR.
使用封闭管系统测量红细胞沉降率（ESR）可降低对实验室工作人员的生物危害风险。Diesse Ves-matic系统提供手动或真空方式将血液采集到塑料管中，自动混合样本，并在沉降20分钟后自动读取终点值。该系统与国际血液学标准化委员会（ICSH）1977年的魏氏ESR方法以及1988年ICSH未稀释ESR方法进行了比较。手动采集的Ves-matic样本与ICSH值显示出良好的一致性，尽管在低ESR值时有出现假低结果的趋势，这可能代表血浆蛋白被过量柠檬酸盐稀释。真空采集的Ves-matic样本与ICSH值也显示出良好的一致性，尽管有出现假高结果的趋势，这可能反映了储存期间塑料管中抗凝剂稀释液或真空丢失导致血液与柠檬酸盐比例的变化。Diesse Ves-matic系统在以前技术的基础上进行了多项改进，提供了更安全、更快且更标准化的ESR检测。
