Mabb A M, Miyamoto S
Program in Molecular and Cellular Pharmacology, Department of Pharmacology, University of Wisconsin, 301 Medical Sciences Center, 1300 University Avenue, Madison, WI 53706, USA.
Cell Mol Life Sci. 2007 Aug;64(15):1979-96. doi: 10.1007/s00018-007-7005-2.
Members of the NF-kappaB family of transcription factors play critical roles in regulating immunity and cell survival and contribute to cancer progression and chemoresistance. Over the past 20 years, much has been learned about the remarkable complexity in regulation of NF-kappaB signaling. In particular, recent studies have added to our current understanding of the roles of a multitude of posttranslational modifications in this signaling system: these include phosphorylation, acetylation, nitrosylation, ubiquitination, neddylation and sumoylation. This review will highlight our current knowledge of the roles of sumoylation in regulating NF-kappaB signaling and functions and will address future perspectives.
转录因子NF-κB家族成员在调节免疫和细胞存活中发挥关键作用，并促进癌症进展和化疗耐药性。在过去20年里，人们对NF-κB信号调节的显著复杂性有了很多了解。特别是，最近的研究增加了我们对该信号系统中多种翻译后修饰作用的当前认识：这些修饰包括磷酸化、乙酰化、亚硝基化、泛素化、NEDD化和类泛素化。本综述将重点介绍我们目前对类泛素化在调节NF-κB信号和功能中的作用的认识，并探讨未来的研究方向。
