Patel Sanjay A, Benzo Roberto P, Slivka William A, Sciurba Frank C
Division of Pulmonary, Allergy, and Critical Care Medicine, University of Pittsburgh, Pittsburgh, PA, USA.
COPD. 2007 Jun;4(2):107-12. doi: 10.1080/15412550701246658.
There is increasing interest in the objective measurement of physical activity in chronic obstructive pulmonary disease (COPD) patients due to the close relationship between physical activity level, health, disability and mortality. We aimed to (a) determine the validity and reproducibility of an activity monitor that integrates accelerometry with multiple physiologic sensors in the determination of energy expenditure in COPD subjects and (b) to document the independent contribution of the additional physiologic sensors to accelerometry measures in improving true energy expenditure determination. Eight subjects (4 male, FEV(1) 56.4 +/- 14.1%, RV 145.0 +/- 75.7%) performed 2 separate 6-minute walk and 2 incremental shuttle walk exercise tests. Energy expenditure was calculated during each exercise test using the physiologic activity monitor and compared to a validated exhaled breath metabolic system. Test-retest reproducibility of physiologic activity monitor during the walking tests was comparable to an exhaled breath metabolic system. Physiologic sensor data significantly improved the explained variance in energy expenditure determination (r(2)=0.88) compared to accelerometry data alone (r(2)=0.68). This physiologic activity monitor provides a valid and reproducible estimate of energy expenditure during slow to moderate paced walking in a laboratory setting and represents an objective method to assess activity in COPD subjects.
由于身体活动水平、健康状况、残疾程度和死亡率之间存在密切关系，慢性阻塞性肺疾病（COPD）患者身体活动的客观测量受到越来越多的关注。我们旨在：（a）确定一种将加速度计与多个生理传感器相结合的活动监测器在测定COPD受试者能量消耗方面的有效性和可重复性；（b）记录额外生理传感器对加速度计测量在改善真实能量消耗测定方面的独立贡献。八名受试者（4名男性，第1秒用力呼气容积（FEV₁）为56.4±14.1%，残气量（RV）为145.0±75.7%）分别进行了两次6分钟步行和两次递增往返步行运动测试。在每次运动测试期间，使用生理活动监测器计算能量消耗，并与经过验证的呼出气代谢系统进行比较。步行测试期间生理活动监测器的重测可重复性与呼出气代谢系统相当。与单独的加速度计数据（r² = 0.68）相比，生理传感器数据显著提高了能量消耗测定中的可解释方差（r² = 0.88）。这种生理活动监测器在实验室环境中对慢至中等步速步行期间的能量消耗提供了有效且可重复的估计，代表了一种评估COPD受试者活动水平的客观方法。
