Kodama Satoru, Tanaka Shiro, Saito Kazumi, Shu Miao, Sone Yasuko, Onitake Fumiko, Suzuki Emiko, Shimano Hitoshi, Yamamoto Shigeru, Kondo Kazuo, Ohashi Yasuo, Yamada Nobuhiro, Sone Hirohito
Department of Lifestyle Medicine and Nutritional Sciences, Ochanomizu University, 2-1-1 Otsuka, Bunkyo-ku, Tokyo, Japan 112-8610.
Arch Intern Med. 2007 May 28;167(10):999-1008. doi: 10.1001/archinte.167.10.999.
Aerobic exercise is believed to reduce the risk of cardiovascular disease partially through increasing serum levels of high-density lipoprotein cholesterol (HDL-C). However, this effect varies considerably among exercise intervention studies.
Electronic database searches of MEDLINE (1966-2005) for randomized controlled trials that examined the effect of exercise training on HDL-C level.
Twenty-five articles were included. Mean net change in HDL-C level was statistically significant but modest (2.53 mg/dL [0.065 mmol/L]; P<.001). Minimal weekly exercise volume for increasing HDL-C level was estimated to be 900 kcal of energy expenditure per week or 120 minutes of exercise per week. Univariate regression analysis indicated that every 10-minute prolongation of exercise per session was associated with an approximately 1.4-mg/dL (0.036-mmol/L) increase in HDL-C level. In contrast, there was no significant association between exercise frequency or intensity. Multiple meta-regression analyses demonstrated that subjects with a body mass index (calculated as weight in kilograms divided by height in meters squared) less than 28 and total cholesterol level of 220 mg/dL [5.7 mmol/L] or more experienced an approximately 2.1-mg/dL (0.054-mmol/L) larger increase in HDL-C level than those with a body mass index of 28 or more and total cholesterol level less than 220 mg/dL (5.7 mmol/L).
Regular aerobic exercise modestly increases HDL-C level. There appears to exist a minimum exercise volume for a significant increase in HDL-C level. Exercise duration per session was the most important element of an exercise prescription. Exercise was more effective in subjects with initially high total cholesterol levels or low body mass index.
有氧运动被认为部分通过提高血清高密度脂蛋白胆固醇（HDL-C）水平来降低心血管疾病风险。然而，这种效果在运动干预研究中差异很大。
通过电子数据库检索MEDLINE（1966 - 2005年）中关于运动训练对HDL-C水平影响的随机对照试验。
纳入25篇文章。HDL-C水平的平均净变化具有统计学意义但幅度较小（2.53mg/dL[0.065mmol/L]；P<0.001）。估计每周增加HDL-C水平所需的最小运动量为每周900千卡能量消耗或每周120分钟运动。单因素回归分析表明，每次运动每延长10分钟，HDL-C水平大约增加1.4mg/dL（0.036mmol/L）。相比之下，运动频率或强度之间无显著关联。多元Meta回归分析表明，体重指数（计算方法为体重千克数除以身高米数的平方）小于28且总胆固醇水平为220mg/dL[5.7mmol/L]或更高的受试者，其HDL-C水平的增加幅度比体重指数为28或更高且总胆固醇水平低于220mg/dL（5.7mmol/L）的受试者大约高2.1mg/dL（0.054mmol/L）。
规律的有氧运动适度增加HDL-C水平。似乎存在一个使HDL-C水平显著增加的最小运动量。每次运动的持续时间是运动处方中最重要的因素。运动对初始总胆固醇水平高或体重指数低的受试者更有效。
