Vaanholt L M, Meerlo P, Garland T, Visser G H, van Dijk G
University of Groningen, Department of Behavioural Biology, Haren, The Netherlands.
Horm Metab Res. 2007 May;39(5):377-83. doi: 10.1055/s-2007-976542.
Mice selectively bred for high wheel-running activity (S) have decreased fat content compared to mice from randomly bred control (C) lines. We explored whether this difference was associated with alterations in levels of circulating hormones involved in regulation of food intake and energy balance, and whether alterations were caused by the presence of a running wheel. Plasma levels of leptin, adiponectin, and corticosterone as well as body composition were analyzed in male S mice housed with (+) and without (-) access to running wheels at ages of 10 and 18 months. These levels were compared to those found in C+ mice. Plasma corticosterone did not differ among groups. While plasma leptin levels tended to be lower in S+ mice as compared to S- or C+ mice, these differences were largely attributable to differences in fat content. Adiponectin levels were increased in S mice (+60%) compared to C mice, irrespective of wheel access. High levels of this hormone may be a trait co-segregated in mice bred for high wheel-running activity.
与随机繁殖的对照（C）系小鼠相比，经选择性培育以获得高跑步活动量的小鼠（S）脂肪含量降低。我们探究了这种差异是否与参与食物摄入和能量平衡调节的循环激素水平变化有关，以及这些变化是否由跑步机的存在引起。在10和18月龄时，对有（+）和无（-）跑步机使用机会的雄性S小鼠的瘦素、脂联素和皮质酮血浆水平以及身体组成进行了分析。将这些水平与C +小鼠中的水平进行比较。各组间血浆皮质酮无差异。虽然与S-或C +小鼠相比，S +小鼠的血浆瘦素水平往往较低，但这些差异很大程度上归因于脂肪含量的差异。与C小鼠相比，S小鼠的脂联素水平升高（60%），无论是否有跑步机使用机会。这种激素的高水平可能是在为高跑步活动量而培育的小鼠中共同分离的一个性状。
