Basterfield L, Lumley L K, Mathers J C
Human Nutrition Research Centre, Institute of Health and Society, Newcastle University, Newcastle upon Tyne, UK.
Int J Obes (Lond). 2009 Feb;33(2):212-8. doi: 10.1038/ijo.2008.253. Epub 2009 Jan 13.
To examine the impact of two diets differing in fat content and of wheel-running exercise on body mass.
A total of 32 female C57BL/6J mice were assigned to either a high-fat (HF, 41% of dietary energy as fat) or low-fat (LF, 11% of dietary energy as fat) diet (16 per diet, individually housed). Eight mice from each diet group were housed with running wheels. Non-running mice were housed in similar cages, without wheels. Total cage activity (including non-exercise physical activity +wheel running) and sleep time were also measured using an infra-red-sensing device. Oestrus stage of the wheel-running mice was assessed daily for 17 days.
After 8 weeks, HF mice were significantly heavier than LF mice (P=0.004), but there was no detectable difference in body fat mass. Wheel-running mice tended to have a lower body mass than non-running controls (P=0.056). Voluntary cage activity was greater in LF control mice than HF control mice, and in wheel-running mice compared with non-wheel-running mice. HF control mice slept more than LF control mice. Stage of oestrus was significantly correlated with running distance, with mice running farthest in the immediate preoestrus phase and least immediately after oestrus.
This study shows that HF diets in female C57BL/6J mice may increase sleep time similar to the effect of daytime sleepiness observed in obese humans.
研究两种脂肪含量不同的饮食以及跑步锻炼对体重的影响。
将32只雌性C57BL/6J小鼠分为高脂（HF，膳食能量的41%为脂肪）或低脂（LF，膳食能量的11%为脂肪）饮食组（每组16只，单独饲养）。每个饮食组中的8只小鼠配备跑步轮。不跑步的小鼠饲养在类似的笼子里，没有跑步轮。还使用红外感应装置测量总笼内活动量（包括非运动性身体活动+跑步）和睡眠时间。对配备跑步轮的小鼠的发情期进行了为期17天的每日评估。
8周后，HF组小鼠明显比LF组小鼠重（P=0.004），但体脂量没有可检测到的差异。配备跑步轮的小鼠体重往往低于不跑步的对照组（P=0.056）。LF组对照小鼠的自主笼内活动量大于HF组对照小鼠，配备跑步轮的小鼠的自主笼内活动量大于未配备跑步轮的小鼠。HF组对照小鼠比LF组对照小鼠睡眠时间更长。发情期与跑步距离显著相关，小鼠在发情前期即将到来时跑得最远，在发情期刚结束后跑得最少。
本研究表明，雌性C57BL/6J小鼠的高脂饮食可能会增加睡眠时间，类似于在肥胖人类中观察到的白天嗜睡的效果。
