Imaizumi Y, Yamamura H, Nishikawa M, Matsuoka M, Moriyama I
Institute of Population Problems, Ministry of Health and Welfare, Tokyo, Japan.
Jinrui Idengaku Zasshi. 1991 Sep;36(3):275-87. doi: 10.1007/BF01910546.
The frequencies of congenital malformations at St. Barnabas' Hospital, Osaka were studied during the period 1948-1990. There were 1,418 malformed infants diagnosed during the first week of life among a total number of 131,996 births during the period. Of the 1.07% of malformed children, 0.90% had single and 0.17% had multiple malformations. The birth prevalence was 1.07% in singletons and 1.20% in twins. There was significant difference in prevalence between males (1.15%) and females (0.97%). The prevalence was 0.88% for the period 1948-1958 and increased with each year cohort up to the recent period when the value was 1.38%. Varus deformities of feet was the most common defect (23.4 per 10,000 births), followed by polydactyly (finger) (7.8), anencephaly (7.1), cleft lip and palate (6.5), syndactyly (toe) (6.5), cleft lip (6.3), and Down's syndrome (6.1). The prevalence of conjoined twins was 1 in 65,551 deliveries. Significant differences occurred between males and females for cleft palate, cleft lip and palate, syndactyly (finger), oligodactyly (finger), and hypoplastic auricle. The prevalences for valgus deformities of feet, syndactyly (toe) and atresia ani increased significantly with the year cohort, whereas the prevalence of cleft palate decreased significantly with the year cohort. Overall prevalence was significantly higher in 1970-1990 (1.28% than in 1948-1969 (0.88%). Similar results were examined for cleft lip and palate, syndactyly (finger), syndactyly (toe), hypospadias, hydrocele testis, and Down's syndrome.
对1948年至1990年期间大阪圣巴拿巴医院先天性畸形的发生率进行了研究。在此期间的131,996例出生婴儿中，有1,418例在出生后第一周被诊断为畸形婴儿。在1.07%的畸形儿童中，0.90%为单发畸形，0.17%为多发畸形。单胎的出生患病率为1.07%，双胎为1.20%。男性（1.15%）和女性（0.97%）的患病率存在显著差异。1948年至1958年期间的患病率为0.88%，并且随着每一年代组的推移而上升，直至最近时期达到1.38%。足内翻畸形是最常见的缺陷（每10,000例出生中有23.4例），其次是多指（趾）畸形（7.8例）、无脑儿（7.1例）、唇腭裂（6.5例）、并趾畸形（6.5例）、唇裂（6.3例）和唐氏综合征（6.1例）。联体双胎的患病率为每65,551例分娩中有1例。腭裂、唇腭裂、并指（趾）畸形、少指（趾）畸形和小耳畸形在男性和女性之间存在显著差异。足外翻畸形、并趾畸形和肛门闭锁的患病率随年代组显著增加，而腭裂的患病率随年代组显著下降。1970年至1990年的总体患病率（1.28%）显著高于1948年至1969年（0.88%）。对唇腭裂、并指（趾）畸形、尿道下裂、睾丸鞘膜积液和唐氏综合征也进行了类似的结果检验。
