Olivencia-Simmons Ivelisse
Frances Payne Bolton School of Nursing, Case Western Reserve University, Cleveland, Ohio 44106, USA.
J Am Acad Nurse Pract. 2007 Jun;19(6):315-20. doi: 10.1111/j.1745-7599.2007.00231.x.
To provide nurse practitioners with a basic understanding of the clinical presentation, diagnosis, diagnostic testing, pharmacological treatment, and prevalence of Wegener's granulomatosis (WG).
Published research and clinical articles, and a case report.
WG is a systemic disease characterized by vasculitis, necrosis, and granulomas. The diagnosis of WG is difficult, particularly early in the disease process. In order to confirm the diagnosis, the patient should undergo specific tests such as antineutrophil cytoplasm antibodies, erythrocyte sedimentation rate, C-reactive protein, and biopsy of the tissue involved.
The diagnosis of WG is often delayed because of the vague symptoms on presentation. Initial symptoms, such as chronic fatigue, upper respiratory infection, sinusitis, and otitis media are common and may not be alarming. Recognizing symptoms, ordering diagnostic tests, and providing appropriate pharmacological therapy is key to diagnosing and treating WG.
为执业护士提供关于韦格纳肉芽肿（WG）的临床表现、诊断、诊断检测、药物治疗及患病率的基本认识。
已发表的研究和临床文章，以及一份病例报告。
WG是一种以血管炎、坏死和肉芽肿为特征的全身性疾病。WG的诊断困难，尤其是在疾病进程早期。为确诊，患者应接受特定检测，如抗中性粒细胞胞浆抗体、红细胞沉降率、C反应蛋白以及受累组织活检。
由于初诊时症状不明确，WG的诊断常被延迟。初始症状，如慢性疲劳、上呼吸道感染、鼻窦炎和中耳炎很常见，可能不会引起警觉。识别症状、安排诊断检测并提供适当的药物治疗是诊断和治疗WG的关键。
