Nilsagard Ylva, Lundholm Cecilia, Gunnarsson Lars-Gunnar, Dcnison Eva
Department of Physiotherapy, Orebro University Hospital, Institution of Clinical Medicine, University of Orebro.
Physiother Res Int. 2007 Jun;12(2):105-14. doi: 10.1002/pri.358.
One must understand the potentials and limitations of all tests used to evaluate interventions. The aim of the present study was to clarify the reproducibility, smallest percentage difference needed to be able to detect a genuine change and correlation regarding the 10-m and 30-m timed walks (10TW 30TW) and the 'timed up and go' (TUG) test in people with moderate multiple sclerosis (MS).
A repeated-measures design was used, with randomization into two groups and different time intervals used for testing. The 10TW and 30TW were performed three times and TUG twice at each testing. Self-selected speed was used for 10TW and forced speed (quickly but safely) for 30TW and TUG. Forty-three people were tested on three occasions within one week. Each person was tested at approximately the same time of the day and by the same physiotherapist on each occasion.
The reproducibility was very high. For a single testing occasion, the intraclass correlation was 0.97 for the 10TW and 0.98 for the 30TW and TUG. The smallest percentage difference needed to be able to detect a genuine change in the entire study group was approximately -23% or +31% for either the 1OTW or TUG. It was evident from the 30TW testing results that lower values applied to those with less (-14% to +17%) rather than more (-38% or +60%) disability. The correlation between all tests for the entire study group was 0.85 (0.76-0.91).
It is sufficient to use only one attempt and to choose only one of the tests when evaluating people with moderate MS. In the case of the 30TW greater attention must be paid to the degree of disability when determining the smallest percentage difference needed to establish a genuine change, than
必须了解用于评估干预措施的所有测试的潜力和局限性。本研究的目的是阐明中度多发性硬化症（MS）患者在10米和30米定时步行（10TW、30TW）以及“起立行走”（TUG）测试方面的可重复性、检测真正变化所需的最小百分比差异以及相关性。
采用重复测量设计，随机分为两组，并使用不同的时间间隔进行测试。每次测试时，10TW和30TW各进行三次，TUG进行两次。10TW采用自选速度，30TW和TUG采用强制速度（快速但安全）。43人在一周内接受了三次测试。每个人在每天大致相同的时间接受测试，每次测试由同一名物理治疗师进行。
可重复性非常高。对于单次测试，10TW的组内相关性为0.97，30TW和TUG的组内相关性为0.98。在整个研究组中，能够检测到真正变化所需的最小百分比差异，对于10TW或TUG约为-23%或+31%。从30TW测试结果可以明显看出，较低的值适用于残疾程度较轻（-14%至+17%）而非较重（-38%或+60%）的患者。整个研究组所有测试之间的相关性为0.85（0.76 - 0.91）。
在评估中度MS患者时，仅进行一次测试并仅选择其中一项测试就足够了。对于30TW，在确定检测真正变化所需的最小百分比差异时，必须比……更加关注残疾程度。
