Sebastião Emerson, Sandroff Brian M, Learmonth Yvonne C, Motl Robert W
Department of Kinesiology and Community Health, University of Illinois at Urbana-Champaign, Urbana, IL.
Department of Kinesiology and Community Health, University of Illinois at Urbana-Champaign, Urbana, IL.
Arch Phys Med Rehabil. 2016 Jul;97(7):1072-7. doi: 10.1016/j.apmr.2015.12.031. Epub 2016 Mar 2.
To examine the validity of the timed Up and Go (TUG) test as a measure of functional mobility in persons with multiple sclerosis (MS) by using a comprehensive framework based on construct validity (ie, convergent and divergent validity).
Cross-sectional study.
Hospital setting.
Community-residing persons with MS (N=47).
Not applicable.
Main outcome measures included the TUG test, timed 25-foot walk test, 6-minute walk test, Multiple Sclerosis Walking Scale-12, Late-Life Function and Disability Instrument, posturography evaluation, Activities-specific Balance Confidence scale, Symbol Digits Modalities Test, Expanded Disability Status Scale, and the number of steps taken per day.
The TUG test was strongly associated with other valid outcome measures of ambulatory mobility (Spearman rank correlation, rs=.71-.90) and disability status (rs=.80), moderately to strongly associated with balance confidence (rs=.66), and weakly associated with postural control (ie, balance) (rs=.31). The TUG test was moderately associated with cognitive processing speed (rs=.59), but not associated with other nonambulatory measures (ie, Late-Life Function and Disability Instrument-upper extremity function).
Our findings support the validity of the TUG test as a measure of functional mobility. This warrants its inclusion in patients' assessment alongside other valid measures of functional mobility in both clinical and research practice in persons with MS.
通过使用基于结构效度（即收敛效度和发散效度）的综合框架，检验定时起立行走（TUG）测试作为多发性硬化症（MS）患者功能活动能力衡量指标的有效性。
横断面研究。
医院环境。
居住在社区的MS患者（N = 47）。
不适用。
主要结局指标包括TUG测试、25英尺定时步行测试、6分钟步行测试、多发性硬化症步行量表-12、老年功能与残疾量表、姿势描记法评估、特定活动平衡信心量表、符号数字模态测试、扩展残疾状态量表以及每日步数。
TUG测试与其他有效的动态活动能力结局指标（Spearman等级相关性，rs = 0.71 - 0.90）和残疾状态（rs = 0.80）密切相关，与平衡信心中度至高度相关（rs = 0.66），与姿势控制（即平衡）弱相关（rs = 0.31）。TUG测试与认知处理速度中度相关（rs = 0.59），但与其他非动态测量指标（即老年功能与残疾量表 - 上肢功能）无关。
我们的研究结果支持TUG测试作为功能活动能力衡量指标的有效性。这使得在MS患者的临床和研究实践中，它有必要与其他有效的功能活动能力测量指标一起纳入患者评估。
