Anneser Johanna M H, Jox Ralf J, Borasio Gian Domenico
Department of Neurology, University of Munich, Germany.
Amyotroph Lateral Scler. 2007 Jun;8(3):189-90. doi: 10.1080/17482960601073543.
In a subset of patients, ALS is associated with frontotemporal dysfunction (ALS-FTD). Clinically, ALS-FTD may present with a variable spectrum of cognitive and behavioural deficits. We report a 53-year-old ALS-FTD patient developing inappropriate sexual behaviour (ISB) manifesting as a vigorous sexual drive with exhausting demands for sexual intercourse and physical aggressions against his wife. This distressing symptom could be alleviated with the selective serotonin reuptake inhibitor sertraline. ISB is an embarrassing symptom for most patients and their caregivers and may therefore be under-reported. Since effective treatment is available, we suggest an open and proactive discussion of sexual issues in this patient group.
在一部分患者中，肌萎缩侧索硬化症（ALS）与额颞叶功能障碍（ALS-FTD）相关。临床上，ALS-FTD可能表现出一系列不同的认知和行为缺陷。我们报告了一名53岁的ALS-FTD患者出现不适当性行为（ISB），表现为强烈的性欲，对性交有过度要求并对其妻子有身体侵犯行为。这种令人痛苦的症状可通过选择性5-羟色胺再摄取抑制剂舍曲林得到缓解。ISB对大多数患者及其照料者来说是一种尴尬的症状，因此可能报告不足。鉴于有有效的治疗方法，我们建议对该患者群体的性问题进行开放和积极的讨论。
