Brennan Renee M, Genco Robert J, Wilding Gregory E, Hovey Kathleen M, Trevisan Maurizio, Wactawski-Wende Jean
Department of Social and Preventive Medicine, School of Public Health and Health Professions, University at Buffalo, State University of New York, Buffalo, NY 14212, USA.
J Periodontol. 2007 Jun;78(6):1051-61. doi: 10.1902/jop.2007.060436.
Oral bacteria are widely recognized in the etiology of periodontal disease. We investigated the prevalence of subgingival bacterial infection with eight species, tested associations between infection and oral bone loss, and assessed potential confounding factors and effect modifiers of those associations in a large community-based cohort of postmenopausal women.
A cross-sectional study of oral health and osteoporosis in 1,256 postmenopausal women recruited from the Buffalo, New York Women's Health Initiative Observational Study was conducted. Standardized dental radiographs were used to measure alveolar crestal height (ACH). Subgingival plaque samples were taken, and the presence of eight bacterial species was assessed by indirect immunofluorescent microscopy in each participant.
The most prevalent infection was Streptococcus sanguis (59.5%), followed by Prevotella intermedia (43.4%), Tannerella forsythensis (37.9%), Capnocytophaga sp. (36.9%), Eubacterium saburreum (32.7%), Campylobacter rectus (17.4%), Porphyromonas gingivalis (15.1%), and Fusobacterium nucleatum (14.2%). Infections with P. gingivalis, T. forsythensis, P. intermedia, and C. rectus were associated with an increased likelihood of having oral bone loss as measured by ACH, even after adjustment for age, smoking, and income. The body mass index (BMI) was a modifier of this association. Overweight women with T. forsythensis infection were more likely to have oral bone loss (OR = 3.37; 95% confidence interval [CI]: 2.08 to 5.46) than normal weight (OR = 1.27; 95% CI: 0.82 to 1.98) or obese (OR = 1.26, 95% CI: 0.72 to 2.20) women with T. forsythensis infection.
The prevalence of specific bacterial infections was determined for a large group of postmenopausal women. Those with infection were more likely to have oral bone loss. Further studies should investigate potential modifying effects of BMI and/or inflammatory factors.
口腔细菌在牙周病病因学中已得到广泛认可。我们在一个以社区为基础的大型绝经后女性队列中，调查了8种龈下细菌感染的患病率，测试了感染与口腔骨质流失之间的关联，并评估了这些关联的潜在混杂因素和效应修饰因素。
对从纽约州布法罗市妇女健康倡议观察性研究中招募的1256名绝经后女性进行了口腔健康与骨质疏松的横断面研究。使用标准化牙科X光片测量牙槽嵴高度（ACH）。采集龈下菌斑样本，通过间接免疫荧光显微镜评估每位参与者中8种细菌的存在情况。
最常见的感染是血链球菌（59.5%），其次是中间普氏菌（43.4%）、福赛坦氏菌（37.9%）、嗜二氧化碳噬纤维菌属（36.9%）、纤细真杆菌（32.7%）、直肠弯曲菌（17.4%）、牙龈卟啉单胞菌（15.1%）和具核梭杆菌（14.2%）。即使在调整了年龄、吸烟和收入因素后，牙龈卟啉单胞菌、福赛坦氏菌、中间普氏菌和直肠弯曲菌感染与通过ACH测量的口腔骨质流失可能性增加有关。体重指数（BMI）是这种关联的效应修饰因素。与体重正常（OR = 1.27；95%置信区间[CI]：0.82至1.98）或肥胖（OR = 1.26，95%CI：0.72至2.20）的福赛坦氏菌感染女性相比，超重的福赛坦氏菌感染女性更有可能出现口腔骨质流失（OR = 3.37；95%CI：2.08至5.46）。
确定了一大群绝经后女性中特定细菌感染的患病率。感染这些细菌的女性更有可能出现口腔骨质流失。进一步的研究应调查BMI和/或炎症因子的潜在修饰作用。
