Stewart Christine P, Katz Joanne, Khatry Subarna K, LeClerq Steven C, Shrestha Sharada Ram, West Keith P, Christian Parul
Department of International Health, Center for Human Nutrition, Johns Hopkins Bloomberg School of Public Health, 615 N. Wolfe Street, Room W2505, Baltimore, MD 21205-2103, USA.
Matern Child Nutr. 2007 Jul;3(3):174-85. doi: 10.1111/j.1740-8709.2007.00097.x.
Pregnancy during adolescence is associated with adverse birth outcomes, including preterm delivery and low birthweight. The nutrient availability to the fetus may be limited if the mother is still growing. This research aims to study the effects of pregnancy during adolescence in a nutritionally poor environment in rural Nepal. This study utilized data from a randomized controlled trial of micronutrient supplementation during pregnancy in south-eastern Nepal. Women of parity 0 or 1 and of age <or= 25 years who gave birth to a singleton liveborn infant who was measured within 72 h of delivery were included (n = 1393). There was no difference in the risk of low birthweight (OR = 0.96; 95% CI = 0.90-1.02) or small for gestational age (OR = 1.01; 95% CI = 0.94-1.08) per year of increasing maternal age among primiparae. Young maternal age did not affect the anthropometry or gestational age of the offspring of parity 1 women. Each year of increasing maternal age among primiparae was associated with increases in birth length (0.07 cm; 95% CI = -0.01 to 0.16), head (0.05 cm; 95% CI = 0.01-0.09) and chest circumference (0.07 cm; 95% CI = 0.01-0.12), but not weight (9.0 g; 95% CI = -2.1 to 21.8) of their offspring. Young maternal age was associated with an increased risk of preterm delivery among primiparae (OR = 2.07; 95% CI = 1.26-3.38) that occurred at an age cut-off of <or=18 years relative to those 19-25 years. Thus, we conclude that young maternal age (<or=18 years) increased the risk of preterm delivery, but not intrauterine growth retardation, for the first but not second liveborn infant.
青春期怀孕与不良分娩结局相关，包括早产和低出生体重。如果母亲仍在生长发育，胎儿可获得的营养物质可能会受到限制。本研究旨在探讨尼泊尔农村营养匮乏环境下青春期怀孕的影响。本研究利用了尼泊尔东南部一项关于孕期补充微量营养素的随机对照试验的数据。纳入了分娩时孕周为0或1且年龄≤25岁、分娩出单胎活产婴儿且在出生后72小时内进行测量的女性（n = 1393）。初产妇中，母亲年龄每增加一岁，低出生体重风险（OR = 0.96；95% CI = 0.90 - 1.02）或小于胎龄儿风险（OR = 1.01；95% CI = 0.94 - 1.08）无差异。年轻的母亲年龄并未影响经产妇后代的人体测量指标或孕周。初产妇中，母亲年龄每增加一岁，其后代的出生身长增加（0.07 cm；95% CI = -0.01至0.16）、头围增加（0.05 cm；95% CI = 0.01 - 0.09）、胸围增加（0.07 cm；95% CI = 0.01 - 0.12），但体重增加不明显（9.0 g；95% CI = -2.1至21.8）。年轻的母亲年龄与初产妇早产风险增加相关（OR = 2.07；95% CI = 1.26 - 3.38），相对于19 - 25岁的初产妇，年龄≤18岁的初产妇发生早产的风险更高。因此，我们得出结论，年轻的母亲年龄（≤18岁）会增加第一胎而非第二胎活产婴儿的早产风险，但不会增加宫内生长受限的风险。
