系统性硬化症患者血清中硝基酪氨酸水平升高，硝基酪氨酸是过氧亚硝酸盐生成的标志物。
Increased serum levels of nitrotyrosine, a marker for peroxynitrite production, in systemic sclerosis.
作者信息
Shimizu K, Ogawa F, Muroi E, Hara T, Komura K, Bae S-J, Sato S
机构信息
Department of Dermatology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan.
出版信息
Clin Exp Rheumatol. 2007 Mar-Apr;25(2):281-6.
OBJECTIVE
To determine serum levels of nitrotyrosine (NT), an end product of peroxynitrite (ONOO-), and its clinical association in patients with systemic sclerosis (SSc).
METHODS
Serum NT levels from 25 patients with limited cutaneous SSc (lSSc) and 34 patients with diffuse cutaneous SSc (dSSc) were examined by enzyme-linked immunosorbent assay.
RESULTS
Serum NT levels were elevated in SSc patients compared with normal controls (n = 27), the levels being similar between lSSc and dSSc patients (P < 0.001). SSc patients with elevated NT had higher serum levels of anti- agalactosyl IgG Ab, IgG and IgA than those with normal NT levels (P < 0.05). NT levels correlated inversely with the percentage diffusion capacity for carbon monoxide (DLco) (P < 0.02, r = -0.414, n = 47).
CONCLUSION
These results suggest that ONOO- may play an important role in the clinical manifestations of SSc, especially vascular damage to the lungs, and that ONOO- may be related to immunological abnormalities in SSc.
目的
测定过氧亚硝酸盐（ONOO-）的终产物硝基酪氨酸（NT）的血清水平及其在系统性硬化症（SSc）患者中的临床关联。
方法
采用酶联免疫吸附测定法检测25例局限性皮肤型SSc（lSSc）患者和34例弥漫性皮肤型SSc（dSSc）患者的血清NT水平。
结果
与正常对照者（n = 27）相比，SSc患者血清NT水平升高，lSSc和dSSc患者之间的水平相似（P < 0.001）。NT水平升高的SSc患者的抗半乳糖基IgG抗体、IgG和IgA血清水平高于NT水平正常的患者（P < 0.05）。NT水平与一氧化碳弥散能力百分比（DLco）呈负相关（P < 0.02，r = -0.414，n = 47）。
结论
这些结果表明，ONOO-可能在SSc的临床表现中起重要作用，尤其是对肺部血管的损伤，并且ONOO-可能与SSc的免疫异常有关。
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