Callard Robin E, Harper John I
Immunobiology Unit, Institute of Child Health, University College London, London, UK, WC1N 1EH.
Trends Immunol. 2007 Jul;28(7):294-8. doi: 10.1016/j.it.2007.05.003. Epub 2007 Jun 4.
The skin barrier (stratum corneum) is a major factor for determining the nature of immune response to antigens presented at the skin surface. Genetic abnormalities in skin barrier function are associated with allergy and atopic dermatitis, and removal of the skin barrier by tape stripping results in dominant Th2 responses to protein antigens. Langerhans cells take up antigen applied to skin from which the skin barrier has been removed; they then migrate to draining lymph nodes and initiate typical Th2 responses. These observations lead us to propose that the high frequency of allergic disease in the industrialized world might be due to lifestyle choices that result in loss of integrity of the skin barrier such as excessive washing and exfoliation of the skin.
皮肤屏障（角质层）是决定对皮肤表面呈现的抗原免疫反应性质的主要因素。皮肤屏障功能的基因异常与过敏和特应性皮炎相关，通过胶带剥离去除皮肤屏障会导致对蛋白质抗原产生占主导地位的Th2反应。朗格汉斯细胞摄取应用于已去除皮肤屏障的皮肤的抗原；然后它们迁移至引流淋巴结并引发典型的Th2反应。这些观察结果使我们提出，工业化世界中过敏性疾病的高发病率可能归因于导致皮肤屏障完整性丧失的生活方式选择，如过度清洗和皮肤去角质。
