P223的抗炎、抗氧化及抗菌作用
Anti-inflammatory, antioxidant effects, and antimicrobial effect of P223.
作者信息
Jung Hee-Su, Lee Hye-Won, Kim Kee-Tae, Lee Na-Kyoung, Paik Hyun-Dong
机构信息
Department of Food Science and Biotechnology of Animal Resources, Konkuk University, Seoul, 05029 Republic of Korea.
Megalab. Co., Ltd, Yuseoung-Gu, Daejeon, 34046 Republic of Korea.
出版信息
Food Sci Biotechnol. 2023 Nov 1;33(9):2179-2187. doi: 10.1007/s10068-023-01445-4. eCollection 2024 Jul.
Abstract
This study aimed to investigate the anti-inflammatory, antioxidant, and antimicrobial effects of P223 which is known to have probiotic properties. P223 that had been killed by heat in LPS-induced RAW 264.7 cells decreased nitric oxide (NO) production. Furthermore, it inhibited the expression of proinflammatory cytokines such interleukin (IL)-1β, IL-6, and tumor necrosis factor-alpha (TNF-α). Heat-killed P223 also inhibited the expression of the nuclear factor (NF)-κB cellular signaling pathway, and it showed reactive oxygen species (ROS) reduction. In DPPH, ABTS, and SOD assay, P223 showed a high antioxidant capacity, and inhibited the growth of skin related pathogens including and . This study therefore demonstrated the various functional properties of P223 as probiotics, and suggested the potential for its application as functional material.
摘要
本研究旨在探究已知具有益生菌特性的P223的抗炎、抗氧化和抗菌作用。在脂多糖诱导的RAW 264.7细胞中，经热灭活的P223可降低一氧化氮（NO）的产生。此外，它还抑制促炎细胞因子如白细胞介素（IL）-1β、IL-6和肿瘤坏死因子-α（TNF-α）的表达。热灭活的P223还抑制核因子（NF）-κB细胞信号通路的表达，并显示出活性氧（ROS）的减少。在DPPH、ABTS和超氧化物歧化酶（SOD）测定中，P223表现出较高的抗氧化能力，并抑制包括……和……在内的皮肤相关病原体的生长。因此，本研究证明了P223作为益生菌的各种功能特性，并表明了其作为功能材料应用的潜力。
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