Glunde Kristine, Pathak Arvind P, Bhujwalla Zaver M
JHU ICMIC Program, The Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Trends Mol Med. 2007 Jul;13(7):287-97. doi: 10.1016/j.molmed.2007.05.002. Epub 2007 Jun 4.
The integration of advances in molecular biology, synthetic chemistry and visualization techniques has catapulted imaging into a molecular-functional realm, so that imaging is finding basic-research, preclinical and translational applications in cancer. Currently, molecular-imaging capabilities include the ability to image gene expression, receptors, signaling pathways, apoptosis, multidrug resistance and the extracellular matrix (ECM). Functional-imaging capabilities include the ability to assess angiogenesis, hypoxia and metabolism. Traditionally, imaging has played an important role in cancer diagnosing and determining response to treatment. However, it is the realization of the goal of noninvasively visualizing molecules and molecular pathways and relating these to function that makes multi-modality imaging such an exciting and powerful means for studying a multifaceted disease such as cancer.
分子生物学、合成化学和可视化技术的进展相结合，已将成像技术带入分子功能领域，使得成像技术在癌症的基础研究、临床前研究及转化应用中得以广泛应用。目前，分子成像能力包括对基因表达、受体、信号通路、细胞凋亡、多药耐药性以及细胞外基质（ECM）进行成像的能力。功能成像能力则包括评估血管生成、缺氧和代谢的能力。传统上，成像在癌症诊断和确定治疗反应方面发挥了重要作用。然而，正是实现了无创可视化分子和分子通路并将其与功能相关联这一目标，才使得多模态成像成为研究像癌症这样复杂疾病的一种令人兴奋且强大的手段。
