Arisawa Tomiyasu, Tahara Tomomitsu, Shibata Tomoyuki, Nagasaka Mitsuo, Nakamura Masakatsu, Kamiya Yoshio, Fujita Hiroshi, Hasegawa Shin, Takagi Tamaki, Wang Fang-Yu, Hirata Ichiro, Nakano Hiroshi
Department of Gastroenterology, Fujita Health University, School of Medicine, 1-98, Dengakugakubo, Toyoake, Japan.
Dig Dis Sci. 2007 Jul;52(7):1691-7. doi: 10.1007/s10620-006-9648-5. Epub 2007 Mar 16.
Noncoding microRNAs regulate the expression of various mRNAs. We attempted to clarify the relationship between miR-27a genome polymorphism and chronic gastritis. The study was performed in 179 patients with no evidence of gastric malignancy. The severity of histologic chronic gastritis was classified according to the updated Sydney system. The frequency of miR-27a G allele was 34.6%. Although the frequencies of miR-27a G allele were increased in subjects with peptic ulcer or severe mucosal atrophy, no significant differences were seen. The miR-27a polymorphism showed an interaction with gender in relation to gastric mucosal atrophy (P=.090). In only male subjects, the miR-27a polymorphism was associated with the gastric mucosal atrophy (P=.039) and both atrophy and metaplasia scores in G/G group were significantly higher than those in the other groups. The miR-27a genome region polymorphism may be an important definitive factor to develop the gastric mucosal atrophy in Japanese male subjects.
非编码微小RNA调控各种信使核糖核酸的表达。我们试图阐明miR-27a基因组多态性与慢性胃炎之间的关系。该研究在179例无胃恶性肿瘤证据的患者中进行。组织学慢性胃炎的严重程度根据更新后的悉尼系统进行分类。miR-27a G等位基因的频率为34.6%。虽然在消化性溃疡或严重黏膜萎缩的受试者中miR-27a G等位基因的频率有所增加，但未观察到显著差异。miR-27a多态性在胃黏膜萎缩方面显示出与性别存在相互作用（P = 0.090）。仅在男性受试者中，miR-27a多态性与胃黏膜萎缩相关（P = 0.039），且G/G组的萎缩和化生评分均显著高于其他组。miR-27a基因组区域多态性可能是日本男性受试者发生胃黏膜萎缩的一个重要决定性因素。
