非编码 RNA 与癌症。

Department of Molecular Virology, Immunology and Medical Genetics, Comprehensive Cancer Center, Ohio State University, Columbus, OH 43210, USA.

Int J Mol Sci. 2013 Aug 19;14(8):17085-110. doi: 10.3390/ijms140817085.

The discovery of the biological relevance of non-coding RNA (ncRNAs) molecules represents one of the most significant advances in contemporary molecular biology. Expression profiling of human tumors, based on the expression of miRNAs and other short or long ncRNAs, has identified signatures associated with diagnosis, staging, progression, prognosis, and response to treatment. In this review we will discuss the recent remarkable advancement in the understanding the biological functions of human ncRNAs in cancer, the mechanisms of expression and the therapeutic potential.

非编码 RNA（ncRNAs）分子的生物学相关性的发现是当代分子生物学最重大的进展之一。基于 miRNA 和其他短或长 ncRNAs 的表达的人类肿瘤表达谱分析，已经确定了与诊断、分期、进展、预后和治疗反应相关的特征。在这篇综述中，我们将讨论在理解人类 ncRNAs 在癌症中的生物学功能、表达机制和治疗潜力方面的最新显著进展。