Murphy Brian T, Brodie Peggie, Slebodnick Carla, Miller James S, Birkinshaw Chris, Randrianjanaka Lucien M, Andriantsiferana Rabodo, Rasamison Vincent E, TenDyke Karen, Suh Edward M, Kingston David G I
Department of Chemistry, Virginia Polythecnic Institute, Blasburg, Virginia, USA.
J Nat Prod. 2008 Mar;71(3):325-9. doi: 10.1021/np070487q. Epub 2008 Jan 5.
Bioassay-guided fractionation of an ethanol extract of a Malleastrum sp. afforded three new limonoids, malleastrones A-C ( 1- 3), respectively. Each limonoid contained a rare tetranortriterpenoid skeleton. Structure elucidation of the isolates was carried out by analysis of one- and two-dimensional NMR and X-ray diffraction data. The novel isolates 1 and 2 were tested for antiproliferative activity against a panel of cancer cell lines and exhibited IC 50 values ranging from 0.19 to 0.63 microM.
对一种楝科植物乙醇提取物进行生物测定导向的分离，分别得到了三种新的柠檬苦素，即楝酮A - C（1 - 3）。每种柠檬苦素都含有一种罕见的四降三萜骨架。通过一维和二维核磁共振以及X射线衍射数据分析对分离物进行结构解析。对新分离物1和2针对一组癌细胞系进行抗增殖活性测试，其IC50值范围为0.19至0.63微摩尔。
