von Heijne G
Center for Biomembrane Research, Department of Biochemistry and Biophysics, Stockholm University, Stockholm, Sweden.
J Intern Med. 2007 Jun;261(6):543-57. doi: 10.1111/j.1365-2796.2007.01792.x.
Chances are that you have come across membrane proteins many times in your professional life: ion channels, aquaporins, G-protein-coupled receptors, drug resistance proteins. But it is also quite likely that you have never bothered to think about what the implications are of being a membrane protein, as opposed to a soluble protein. What is special about membrane proteins in terms of structure and function, how many membrane proteins are out there, how are they made in the cell? Welcome to the membrane protein universe!
在你的职业生涯中，你很可能已经多次接触过膜蛋白：离子通道、水通道蛋白、G蛋白偶联受体、耐药蛋白。但你也很可能从未费心去思考过作为一种膜蛋白，与可溶性蛋白相比，意味着什么。膜蛋白在结构和功能方面有什么特别之处，有多少种膜蛋白，它们在细胞中是如何产生的？欢迎来到膜蛋白的世界！
