Vlassara Helen, Striker Gary
Division of Experimental Diabetes and Aging, Department of Geriatrics, Mount Sinai School of Medicine, Box 1640, One Gustave Levy Place, New York, NY 10029, USA.
Curr Diab Rep. 2007 Jun;7(3):235-41. doi: 10.1007/s11892-007-0037-z.
Oxidant stress underlies diabetes and diabetic complications, including cardiovascular, renal, and retinal disease. Advanced glycation end products (AGEs), or glycotoxins, are a significant contributor to oxidant stress in diabetes. The diet is a major, unrecognized source of AGEs. Importantly, reduction of dietary AGEs decreases circulating inflammatory markers in both diabetic patients and prediabetic patients and complications in animal models. This beneficial outcome requires only a 50% decrease in dietary AGEs, making this necessary intervention practical and inexpensive.
氧化应激是糖尿病及其并发症（包括心血管疾病、肾脏疾病和视网膜疾病）的潜在病因。晚期糖基化终产物（AGEs），即糖毒素，是糖尿病氧化应激的重要促成因素。饮食是AGEs的一个主要但未被认识到的来源。重要的是，减少饮食中的AGEs可降低糖尿病患者和糖尿病前期患者的循环炎症标志物，并减少动物模型中的并发症。这种有益的结果仅需要饮食中AGEs减少50%，使得这种必要的干预措施切实可行且成本低廉。
