Younes-Mhenni S, Frih-Ayed M, Kerkeni A, Bost M, Chazot G
Department of Neurology, University Hospital of Monastir, Monastir, Tunisia.
Eur Neurol. 2007;58(2):78-83. doi: 10.1159/000103641. Epub 2007 Jun 12.
Oxidative stress and generation of reactive oxygen species are believed to be implicated in Parkinson's disease (PD). Erythrocyte activity of superoxide dismutase (SOD) and catalase, the blood glutathione system, and plasma levels of thiobarbituric-acid-reactive substances (TBARS) were measured in 80 PD patients. These biochemical parameters were also measured in 29 age-matched controls. Patients with PD had significantly higher red blood corpuscle (RBC) activity of SOD. The mean RBC activity of catalase in PD patients did not differ significantly from those of controls. RBC catalase activity was significantly lower in advanced cases of PD compared to early cases. Oxidized glutathione was significantly higher in RBCs of PD patients, although there were no changes in total glutathione and reduced glutathione compared to controls. TBARS content was increased in patients with PD. Levodopa therapy, age and duration of illness did not significantly influence the measured parameters. Our study supports the previous hypothesis that oxidative stress is implicated in the pathogenesis of PD. Perspectives for treatment of PD in the future could include antioxidant therapy.
氧化应激和活性氧的产生被认为与帕金森病（PD）有关。对80例帕金森病患者测定了红细胞超氧化物歧化酶（SOD）和过氧化氢酶活性、血液谷胱甘肽系统以及血浆硫代巴比妥酸反应性物质（TBARS）水平。还对29名年龄匹配的对照组进行了这些生化参数的测定。帕金森病患者的红细胞（RBC）SOD活性显著更高。帕金森病患者过氧化氢酶的平均红细胞活性与对照组无显著差异。与早期病例相比，帕金森病晚期病例的红细胞过氧化氢酶活性显著更低。帕金森病患者红细胞中的氧化型谷胱甘肽显著更高，尽管与对照组相比，总谷胱甘肽和还原型谷胱甘肽没有变化。帕金森病患者的TBARS含量增加。左旋多巴治疗、年龄和病程对所测参数没有显著影响。我们的研究支持了先前的假设，即氧化应激与帕金森病的发病机制有关。未来帕金森病的治疗前景可能包括抗氧化治疗。
