Wu Xian-Ming, Wu Song-Feng, Ren Da-Ming, Zhu Yun-Ping, He Fu-Chu
College of biological science and technology, Shenyang agriculture university, Shenyang 110161, China.
Yi Chuan. 2007 Apr;29(4):420-6. doi: 10.1360/yc-007-0420.
Codon bias refers to the nonrandom usage of synonymous codons for encoding amino acids in organisms. As it is related to the carrier molecular of genetic information (DNA) and functional molecular (protein) of life, this phenomenon implicates important biological sense. In this review, we summarize the basic theories and analysis methods about codon bias; and present the softwares and websites which are usually used for codon usage analysis. The related fields about codon bias and the research progress are also introduced.
密码子偏好性是指生物体中编码氨基酸的同义密码子的非随机使用。由于它与生命的遗传信息载体分子（DNA）和功能分子（蛋白质）相关，这种现象具有重要的生物学意义。在本综述中，我们总结了关于密码子偏好性的基本理论和分析方法；并介绍了常用于密码子使用分析的软件和网站。还介绍了密码子偏好性的相关领域及其研究进展。
