Goverover Y, Genova H M, Hillary F G, DeLuca J
Kessler Medical Rehabilitation Research and Education Corporation, West Orange, NJ 07052, USA.
Mult Scler. 2007 Jun;13(5):636-44. doi: 10.1177/1352458506072984. Epub 2007 Feb 16.
Multiple sclerosis (MS) can result in cognitive deficits and a loss of functional independence. To date, little research has linked the observed cognitive and behavioral deficits in MS, especially those in the processing speed domain, to performance on tasks of everyday functioning. The present study examined the relationship between neuropsychological test performance and performance on the Timed Instrumental Activities of Daily Living task (TIADL) in individuals with MS, and in healthy controls (HCs). The TIADL is a functional measure, which assesses both accuracy and speed in one's performance of everyday activities. The MS group performed significantly worse on the TIADL relative to the HC group. Additionally, TIADL scores of individuals with MS were significantly correlated with neuropsychological measures of processing speed. TIADL scores were not, however, correlated with neuropsychological measures of verbal episodic memory or working memory. These results indicate that the impairments in processing speed may contribute to impairments in activities of everyday living in persons with MS.
多发性硬化症（MS）可导致认知缺陷和功能独立性丧失。迄今为止，很少有研究将MS中观察到的认知和行为缺陷，尤其是处理速度领域的缺陷，与日常功能任务的表现联系起来。本研究考察了MS患者和健康对照者（HCs）的神经心理测试表现与计时日常生活工具性活动任务（TIADL）表现之间的关系。TIADL是一种功能测量方法，评估个体在日常活动中的准确性和速度。与HC组相比，MS组在TIADL上的表现明显更差。此外，MS患者的TIADL得分与处理速度的神经心理测量指标显著相关。然而，TIADL得分与言语情景记忆或工作记忆的神经心理测量指标无关。这些结果表明，处理速度的损害可能导致MS患者日常生活活动的损害。
