Lumelsky Nadya L
National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland 20892, USA.
Tissue Eng. 2007 Jul;13(7):1393-8. doi: 10.1089/ten.2007.0100.
Regenerative medicine aims to restore homeostasis of diseased tissues and organs. With time, engineered replacement tissue constructs will play an increasingly important role in achieving this goal. Equally important, however, will be the ability to resolve disease-associated inflammation and to optimize tissue regenerative capacity by specifically patterning the host tissue microenvironment. The tools of bioengineering are uniquely suited to meet these challenges. Here, the candidate molecular and cellular targets for manipulating the host's inflammatory environment and tissue regenerative capacity are briefly discussed within the context of current and emerging bioengineering strategies. The objective is to draw the attention of basic scientists and engineers to the importance of regulating inflammation in achieving the goals of tissue engineering and regenerative medicine.
再生医学旨在恢复患病组织和器官的内环境稳定。随着时间的推移，工程化替代组织构建体在实现这一目标中将发挥越来越重要的作用。然而，同样重要的是，要有能力解决与疾病相关的炎症，并通过特异性地构建宿主组织微环境来优化组织再生能力。生物工程工具特别适合应对这些挑战。在此，在当前和新兴生物工程策略的背景下，简要讨论了用于操纵宿主炎症环境和组织再生能力的候选分子和细胞靶点。目的是引起基础科学家和工程师对调节炎症在实现组织工程和再生医学目标中的重要性的关注。
