Hashim Hashim, Abrams Paul
Bristol Urological Institute, Southmead Hospital, Bristol, UK.
Curr Opin Urol. 2007 Jul;17(4):231-6. doi: 10.1097/MOU.0b013e32819ed7f9.
Overactive bladder is an important lower urinary tract syndrome that negatively affects the quality of life of millions of people worldwide. Both sexes and all age groups may be affected; therefore many specialists, including urologists, gynaecologists, geriatricians, paediatricians, physiotherapists and continence advisors, are involved in the management of patients with overactive bladder.
There is ongoing research, both basic science and clinical trials, to establish the cause of overactive bladder and to determine the best method of managing patients who suffer from this syndrome. New theories and modified definitions of overactive bladder have been proposed, structured evidence-based management guidelines have been established, more prevalence studies have been conducted and new treatment strategies have emerged.
Overactive bladder is now recognized as a chronic debilitating condition that costs millions of dollars. With an ageing population these costs will increase, and it is necessary that health systems around the world recognize this. Further research into the basic science of the condition is required to identify the true cause of overactive bladder, allowing new targeted treatments to be established.
膀胱过度活动症是一种重要的下尿路综合征，对全球数百万人的生活质量产生负面影响。男女老少均可受累；因此，包括泌尿科医生、妇科医生、老年病医生、儿科医生、物理治疗师和尿失禁顾问在内的许多专家都参与了膀胱过度活动症患者的管理。
目前正在进行基础科学和临床试验方面的研究，以确定膀胱过度活动症的病因，并确定治疗该综合征患者的最佳方法。已经提出了关于膀胱过度活动症的新理论和修正定义，建立了基于证据的结构化管理指南，开展了更多患病率研究，并出现了新的治疗策略。
膀胱过度活动症现在被认为是一种慢性衰弱性疾病，耗费数百万美元。随着人口老龄化，这些费用将会增加，世界各地的卫生系统有必要认识到这一点。需要对该疾病的基础科学进行进一步研究，以确定膀胱过度活动症的真正病因，从而建立新的靶向治疗方法。
