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纳米药理学在转化血液学和肿瘤学中的应用。

Nanopharmacology in translational hematology and oncology.

机构信息

Research Center for Functional Genomics, Biomedicine and Translational Medicine, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania ; Department of Hematology, Ion Chiricuta Cancer Center, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania.

Research Center for Functional Genomics, Biomedicine and Translational Medicine, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania.

出版信息

Int J Nanomedicine. 2014 Jul 22;9:3465-79. doi: 10.2147/IJN.S60488. eCollection 2014.

Abstract

Nanoparticles have displayed considerable promise for safely delivering therapeutic agents with miscellaneous therapeutic properties. Current progress in nanotechnology has put forward, in the last few years, several therapeutic strategies that could be integrated into clinical use by using constructs for molecular diagnosis, disease detection, cytostatic drug delivery, and nanoscale immunotherapy. In the hope of bringing the concept of nanopharmacology toward a viable and feasible clinical reality in a cancer center, the present report attempts to present the grounds for the use of cell-free nanoscale structures for molecular therapy in experimental hematology and oncology.

摘要

纳米颗粒在安全地递呈具有多种治疗特性的治疗剂方面显示出巨大的应用前景。近年来,纳米技术的最新进展提出了多种治疗策略,这些策略可以通过构建分子诊断、疾病检测、细胞毒性药物递呈和纳米级免疫治疗等方法,整合到临床应用中。本报告旨在为实验血液学和肿瘤学中的分子治疗应用无细胞纳米结构提供依据,希望将纳米药理学的概念引入癌症中心,使其成为一种可行的临床现实。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2f8f/4113407/1fdafa1f5f1d/ijn-9-3465Fig1.jpg

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