用于癌症治疗的纳米技术新前沿。

New frontiers in nanotechnology for cancer treatment.

作者信息

Alexis Frank, Rhee June-Wha, Richie Jerome P, Radovic-Moreno Aleksandar F, Langer Robert, Farokhzad Omid C

机构信息

Department of Anesthesiology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.

出版信息

Urol Oncol. 2008 Jan-Feb;26(1):74-85. doi: 10.1016/j.urolonc.2007.03.017.

DOI:10.1016/j.urolonc.2007.03.017

PMID:18190835

Abstract

Nanotechnology is a field of research at the crossroads of biology, chemistry, physics, engineering, and medicine. Design of multifunctional nanoparticles capable of targeting cancer cells, delivering and releasing drugs in a regulated manner, and detecting cancer cells with enormous specificity and sensitivity are just some examples of the potential application of nanotechnology to oncological diseases. In this review we discuss the recent advances of cancer nanotechnology with particular attention to nanoparticle systems that are in clinical practice or in various stages of development for cancer imaging and therapy.

摘要

纳米技术是一个处于生物学、化学、物理学、工程学和医学交叉点的研究领域。能够靶向癌细胞、以可控方式递送和释放药物以及以极高的特异性和灵敏度检测癌细胞的多功能纳米颗粒的设计，只是纳米技术在肿瘤疾病中潜在应用的一些例子。在这篇综述中，我们讨论了癌症纳米技术的最新进展，特别关注了已应用于临床实践或处于癌症成像和治疗不同开发阶段的纳米颗粒系统。