Centre for Child and Adolescent Psychiatry, Bispebjerg University Hospital, 2400 Copenhagen, Denmark.
J Autism Dev Disord. 2012 Apr;42(4):619-24. doi: 10.1007/s10803-011-1286-x.
We compared the prevalence and types of fractures in a clinical sample of 118 individuals diagnosed as children with infantile autism (IA) with 336 matched controls from the general population. All participants were screened through the nationwide Danish National Hospital Register. The average observation time was 30.3 years (range 27.3-30.4 years), and mean age at follow-up was 42.7 years (range 27.3-57.3 years). Of the 118 individuals with IA, 14 (11.9%) were registered with at least one fracture diagnosis against 83 (24.7%) in the comparison group (p = 0.004; OR = 0.41; 95%CI 0.22-0.76), but the nature of their fractures seems somewhat different. Epilepsy was a risk factor, but only in the comparison group. Our results lend no support to the notion that fracture is a common comorbid condition in a population of people diagnosed with IA as children.
我们比较了临床样本中 118 名被诊断为儿童自闭症（IA）的个体与来自普通人群的 336 名匹配对照者的骨折发生率和类型。所有参与者都通过全国丹麦国家医院登记处进行了筛查。平均观察时间为 30.3 年（范围为 27.3-30.4 年），随访时的平均年龄为 42.7 岁（范围为 27.3-57.3 岁）。在 118 名 IA 个体中，有 14 人（11.9%）至少有一次骨折诊断，而对照组中有 83 人（24.7%）（p=0.004；OR=0.41；95%CI 0.22-0.76），但他们的骨折性质似乎有些不同。癫痫是一个危险因素，但仅在对照组中。我们的结果不支持骨折是儿童自闭症人群中常见的共病的观点。
