Mouridsen Svend Erik, Rich Bente, Isager Torben
Centre for Child and Adolescent Psychiatry, Bispebjerg University Hospital, DK 2400 Copenhagen, Denmark.
Kong Valdemars Vej 75, Roskilde, Denmark.
Res Dev Disabil. 2016 Oct;57:193-200. doi: 10.1016/j.ridd.2016.07.002. Epub 2016 Jul 19.
Research dealing with adult people with autism spectrum disorders (ASD) noticeably lags behind studies of children and young individuals with ASD.
The objective of this study was to compare the prevalence and types of diseases of the circulatory system in a clinical sample of 118 adult people diagnosed with infantile autism (IA) as children with 336 sex and age matched controls from the general population.
All participants were screened through the nationwide Danish National Hospital Register. The average observation time of both groups was 37.2 years, and mean age at follow-up was 49.6 years.
Of the 118 people with IA, 11 (9.3%) were registered with at least one disease of the circulatory system against 54 (16.1%) in the comparison group (p=0.09; OR=0.54; 95% CI 0.3-1.2). Ischemic heart diseases occurred significantly more frequently among people in the comparison group (p=0.02).
It is argued that diseases of the circulatory system may be underdiagnosed in people with IA because of the difficulties they face with respect to identifying and communicating symptoms of ill health. Bearing in mind that cardiovascular disease is the primary cause of death in most developed countries, it is suggested that to prevent disease and manage health conditions, health monitoring is essential in adult people with IA.
针对患有自闭症谱系障碍（ASD）的成年人的研究明显滞后于针对患有ASD的儿童和青少年的研究。
本研究的目的是比较118名童年时期被诊断为婴儿自闭症（IA）的成年人临床样本与336名来自普通人群的性别和年龄匹配的对照组中循环系统疾病的患病率和类型。
所有参与者均通过丹麦全国性的国家医院登记册进行筛查。两组的平均观察时间为37.2年，随访时的平均年龄为49.6岁。
在118名患有IA的人中，有11人（9.3%）登记患有至少一种循环系统疾病，而对照组中有54人（16.1%）（p = 0.09；OR = 0.54；95% CI 0.3 - 1.2）。对照组中缺血性心脏病的发生率明显更高（p = 0.02）。
有人认为，由于患有IA的人在识别和传达健康问题症状方面面临困难，循环系统疾病在他们中可能未得到充分诊断。鉴于心血管疾病是大多数发达国家的主要死因，建议为预防疾病和管理健康状况，对患有IA的成年人进行健康监测至关重要。
