儿童期神经行为抑制会增加物质使用障碍的风险：父母病史与产前酒精暴露的相互作用。
Childhood neurobehavior disinhibition amplifies the risk of substance use disorder: interaction of parental history and prenatal alcohol exposure.
作者信息
Chapman Kim, Tarter Ralph E, Kirisci Levent, Cornelius Marie D
机构信息
Department of Pediatrics, University of Pittsburgh Medical Center, Pittsburgh, PA 15261, USA.
出版信息
J Dev Behav Pediatr. 2007 Jun;28(3):219-24. doi: 10.1097/DBP.0b013e3180327907.
OBJECTIVE
This investigation examined the influence of parental substance use disorder (SUD) and mother's alcohol consumption during pregnancy on neurobehavior disinhibition (ND) measured in 10- to 12-year-old children. The extent to which ND predicted SUD outcome 7 to 9 years later was also determined.
METHODS
SUD was documented in each parent and as the outcome variable in their 19-year-old sons. Average daily alcohol consumption during the mother's pregnancy was recorded using a structured interview. ND was assessed using indicators of behavior undercontrol, affect modulation and executive cognitive functions.
RESULTS
Paternal SUD and the interaction between maternal SUD and alcohol consumption during pregnancy predicted child's ND score. ND at 10 to 12 years of age was a significant predictor of SUD at age 19.
CONCLUSIONS
The disinhibitory disturbance associated with risk of SUD has both transmissible and teratogenic causes. The ramifications of this finding for pediatric practice are discussed.
目的
本研究调查了父母物质使用障碍（SUD）以及母亲孕期饮酒对10至12岁儿童神经行为抑制（ND）的影响。同时还确定了ND在7至9年后预测SUD结果的程度。
方法
记录每位父母的SUD情况，并将其作为他们19岁儿子的结果变量。通过结构化访谈记录母亲孕期的平均每日饮酒量。使用行为控制、情感调节和执行认知功能指标评估ND。
结果
父亲的SUD以及母亲的SUD与孕期饮酒之间的相互作用可预测儿童的ND得分。10至12岁时的ND是19岁时SUD的重要预测指标。
结论
与SUD风险相关的抑制障碍既有可传播的原因，也有 teratogenic 原因。讨论了这一发现对儿科实践的影响。 （注：teratogenic 可能是输入错误，推测可能是“致畸的”意思，原文可能想表达“致畸原因” ）
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