Department of Electrical Engineering & Electronics, University of Liverpool, Liverpool, UK.
Integr Biol (Camb). 2009 Feb;1(2):150-69. doi: 10.1039/b814985b. Epub 2008 Dec 9.
Protein molecular motors are natural nano-machines that convert the chemical energy from the hydrolysis of adenosine triphosphate into mechanical work. These efficient machines are central to many biological processes, including cellular motion, muscle contraction and cell division. The remarkable energetic efficiency of the protein molecular motors coupled with their nano-scale has prompted an increasing number of studies focusing on their integration in hybrid micro- and nanodevices, in particular using linear molecular motors. The translation of these tentative devices into technologically and economically feasible ones requires an engineering, design-orientated approach based on a structured formalism, preferably mathematical. This contribution reviews the present state of the art in the modelling of protein linear molecular motors, as relevant to the future design-orientated development of hybrid dynamic nanodevices.
蛋白质分子马达是将三磷酸腺苷水解产生的化学能转化为机械功的天然纳米机器。这些高效机器是许多生物过程的核心，包括细胞运动、肌肉收缩和细胞分裂。蛋白质分子马达的惊人能量效率及其纳米尺度促使越来越多的研究集中于将其整合到混合微纳设备中，特别是使用线性分子马达。这些初步设备向技术和经济上可行的设备的转化需要基于结构化形式主义的工程、设计导向方法，最好是数学方法。本文综述了与混合动态纳米设备未来设计导向开发相关的蛋白质线性分子马达建模的现状。
