被动吸烟、Cyp1A1基因多态性与痛经
Passive smoking, Cyp1A1 gene polymorphism and dysmenorrhea.
作者信息
Liu Hong, Yang Fan, Li Zhiping, Chen Changzhong, Fang Zhian, Wang Lihua, Hu Yonghua, Chen Dafang
机构信息
Department of Epidemiology and Biostatistics, School of Public Health, Peking University Health Science Center, Beijing, China.
出版信息
Reprod Toxicol. 2007 Jul;24(1):114-9. doi: 10.1016/j.reprotox.2007.04.069. Epub 2007 May 7.
OBJECTIVE
This study investigated whether the association between passive smoking exposure and dysmenorrhea is modified by two susceptibility genes, CYP1A1MspI and CYP1A1HincII.
METHODS
This report includes 1645 (1124 no dysmenorrhea, 521 dysmenorrhea) nonsmoking and nondrinking newly wed female workers at Anqing, China between June 1997 and June 2000. Multiple logistic regression models were used to estimate the associations of passive smoking exposure and genetic susceptibility with dysmenorrhea, adjusting for perceived stress.
RESULTS
When stratified by women genotype, the adjusted OR of dysmenorrhea was 1.6 (95%CI=1.3-2.1) for passive smoking group with Ile/Ile462 genotype, and 1.5 (95%CI=1.1-2.1) with C/C6235 genotype, compared to nonpassive smoking group, respectively. The data further showed that there was a significant combined effect between passive smoking and the CYP1A1 MspI C/C6235 and HincII Ile/Ile462 genotype (OR=2.6, 95%CI=1.3-5.2).
CONCLUSION
CYP1A1 MspI and HincII genotypes modified the association between passive smoking and dysmenorrhea.
目的
本研究调查了被动吸烟暴露与痛经之间的关联是否会被两个易感基因CYP1A1MspI和CYP1A1HincII所改变。
方法
本报告纳入了1997年6月至2000年6月期间在中国安庆的1645名（1124名无痛经，521名有痛经）不吸烟且不饮酒的新婚女性工作者。采用多重逻辑回归模型来估计被动吸烟暴露和遗传易感性与痛经之间的关联，并对感知到的压力进行了调整。
结果
按女性基因型分层时，与非被动吸烟组相比，Ile/Ile462基因型的被动吸烟组痛经的调整后比值比为1.6（95%置信区间=1.3 - 2.1），C/C6235基因型的被动吸烟组痛经的调整后比值比为1.5（95%置信区间=1.1 - 2.1）。数据进一步显示，被动吸烟与CYP1A1 MspI C/C6235和HincII Ile/Ile462基因型之间存在显著的联合效应（比值比=2.6，95%置信区间=1.3 - 5.2）。
结论
CYP1A1 MspI和HincII基因型改变了被动吸烟与痛经之间的关联。
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