被动吸烟、细胞色素P450基因多态性与痛经
Passive smoking, cytochrome P450 gene polymorphisms and dysmenorrhea.
作者信息
Lei Lou, Ye Linan, Liu Hong, Chen Changzhong, Fang Zhian, Wang Lihua, Hu Yonghua, Chen Dafang
机构信息
Department of Epidemiology and Biostatistics, School of Public Health, Peking University Health Science Center, 38 Xueyuan Road, Haidian District, Beijing, 100083, China.
出版信息
Eur J Epidemiol. 2008;23(7):475-81. doi: 10.1007/s10654-008-9250-6. Epub 2008 Apr 25.
PURPOSE
This study investigated whether the association between passive smoking exposure and dysmenorrhea is modified by two susceptibility genes, CYP1A1MspI and CYP1A1HincII.
METHODS
This report includes 1,645 (1,124 no dysmenorrhea, 521 dysmenorrhea) non-smoking and non-drinking newly wedding female workers at Anqing, China between June 1997 and June 2000. Multiple logistic regression models were used to estimate the associations of passive smoking exposure and genetic susceptibility with dysmenorrhea, adjusting for maternal age, BMI, age of menarche, education, vibration exposure, shift work, noise exposure, pregnancy history, perceived stress and physical laboring stress.
RESULTS
In the passive smoking group, women who have C/C6235 genotype (OR = 1.8, 95% CI = 1.0-3.3) in CYP1A1MspI and Ile/Ile462 genotype (OR = 2.9, 95% CI = 1.1-7.7) in CYP1A1HincII was associated with an increased risk of dysmenorrhea. When stratified by women genotype, the adjusted OR of dysmenorrheal was 1.6 (95% CI = 1.2-2.1) for passive smoking group with Ile/Ile462 genotype, and 1.5 (95% CI = 1.0-2.1) with C/C6235 genotype, compared to non-passive smoking group, respectively. The data further showed that there was a significant combined effect between passive smoking and the CYP1A1 Msp1C/C6235 (OR = 1.5, 95% CI = 1.0-2.1), and HincII Ile/Ile462 (OR = 1.6, 95% CI = 1.2-2.1), respectively.
CONCLUSION
CYP1A1 MspI and HincII genotypes modified the association between passive smoking and dysmenorrhea.
目的
本研究调查了两种易感基因CYP1A1MspI和CYP1A1HincII是否会改变被动吸烟暴露与痛经之间的关联。
方法
本报告纳入了1997年6月至2000年6月期间在中国安庆的1645名（1124名无痛经，521名有痛经）不吸烟、不饮酒的新婚女性工人。采用多元逻辑回归模型来估计被动吸烟暴露和遗传易感性与痛经之间的关联，并对产妇年龄、体重指数、初潮年龄、教育程度、振动暴露、轮班工作、噪声暴露、妊娠史、感知压力和体力劳动压力进行了调整。
结果
在被动吸烟组中，CYP1A1MspI基因具有C/C6235基因型（比值比=1.8，95%置信区间=1.0-3.3）以及CYP1A1HincII基因具有Ile/Ile462基因型（比值比=2.9，95%置信区间=1.1-7.7）的女性与痛经风险增加相关。按女性基因型分层时，与非被动吸烟组相比，具有Ile/Ile462基因型的被动吸烟组痛经的调整后比值比为1.6（95%置信区间=1.2-2.1），具有C/C6235基因型的被动吸烟组痛经的调整后比值比为1.5（95%置信区间=1.0-2.1）。数据进一步表明，被动吸烟与CYP1A1 Msp1C/C6235（比值比=1.5，95%置信区间=1.0-2.1）以及HincII Ile/Ile462（比值比=1.6，95%置信区间=1.2-2.1）之间分别存在显著的联合效应。
结论
CYP1A1 MspI和HincII基因型改变了被动吸烟与痛经之间的关联。
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