Masuda Akiko, Baba Takayuki, Dohmae Naoshi, Yamamura Masahiro, Wada Hiroo, Ushida Kiminori
Riken (The Institute of Physical and Chemical Research), 2-1 Hirosawa, Wako, Saitama 351-0198, Japan.
J Nat Prod. 2007 Jul;70(7):1089-92. doi: 10.1021/np060341b. Epub 2007 Jun 14.
We extracted a novel glycoprotein, a member of the mucin family, from five species of jellyfish with high yields (1%-3% dry weight, 0.02%-0.1% wet weight) and determined its main chain structure and molecular mass. The glycoprotein contains unique tandem repeats of eight amino acids, of which two threonine residues are probably glycosylated by N-acetyl-d-galactosamine (GalNAc). We named this substance, which is common in jellyfish and similar to the human mucin MUC5AC, "qniumucin" and suggested the utilization of this compound as a new marine resource.
我们从五种水母中高产提取了一种新型糖蛋白，它是粘蛋白家族的一员（产量为干重的1%-3%，湿重的0.02%-0.1%），并确定了其主链结构和分子量。该糖蛋白包含独特的八个氨基酸的串联重复序列，其中两个苏氨酸残基可能被N-乙酰-d-半乳糖胺（GalNAc）糖基化。我们将这种在水母中常见且类似于人类粘蛋白MUC5AC的物质命名为“qniumucin”，并建议将该化合物作为一种新的海洋资源加以利用。
