中国海洋海绵 Spongia officinalis 中的海绵二萜

Spongian diterpenes from Chinese marine sponge Spongia officinalis.

机构信息

State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zu Chong Zhi Road, Zhangjiang Hi-Tech Park, Shanghai 201203, China; The First Affiliated Hospital of Jinzhou Medical University, 2 Renmin Road, Jinzhou 121001, China.

State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zu Chong Zhi Road, Zhangjiang Hi-Tech Park, Shanghai 201203, China; School of Pharmaceutical Sciences, Jinzhou Medical University, Jinzhou 121001, China.

出版信息

Fitoterapia. 2018 Jun;127:159-165. doi: 10.1016/j.fitote.2018.02.010. Epub 2018 Feb 12.

DOI:10.1016/j.fitote.2018.02.010

PMID:29447982

Abstract

3-Nor-spongiolide A (1), belonging to the extremely rare 3-nor-spongian carbon skeleton, and spongiolides A (2) and B (3), having γ-butenolide instead of furan ring as usual for ring D, together with six related known metabolites were isolated from South China Sea sponge Spongia officinalis as its metabolic components. Their structures were elucidated on the basis of extensive spectroscopic analysis. The absolute configurations of three new compounds 1-3 were determined by ECD calculations.

摘要

3-去甲海绵甾内酯 A（1），属于极为罕见的 3-去甲海绵甾烷骨架，以及海绵甾内酯 A（2）和 B（3），其环 D 通常为γ-丁烯内酯而不是呋喃环，与六个相关的已知代谢物一起从南海海绵 Spongia officinalis 中分离出来作为其代谢产物。它们的结构是通过广泛的光谱分析阐明的。三个新化合物 1-3 的绝对构型通过 ECD 计算确定。