Wong C M, Critchley L A, Lee A, Khaw K S, Ngan Kee W D
Department of Anaesthesia & Intensive Care, Prince of Wales Hospital, Shatin, New Territories, Hong Kong.
Anaesthesia. 2007 Jul;62(7):654-60. doi: 10.1111/j.1365-2044.2007.05057.x.
Probit analysis was used to predict an optimal dose of fentanyl, co-administered with propofol 2.5 mg.kg(-1), when inserting the laryngeal mask airway. In all, 21 male and 54 female healthy Chinese patients, aged 18-63 years, requiring anaesthesia for minor surgery were recruited. They were assigned to one of five groups: placebo, 0.5, 1.0, 1.5 and 2.0 microg.kg(-1). Insertion was performed 90 s after administration and insertion conditions assessed using a six-category score. Dose-response curves could only be drawn for swallowing and movement categories, and only the ED(50) could be predicted with certainty. To provide optimal conditions in over 95% of patients, fentanyl doses well above the clinical range were required. A standard fentanyl dose of 1 mug.kg(-1), co-administered with propofol 2.5 mg.kg(-1), provided optimal conditions in 65% of cases. Ninety seconds may have been insufficient time for fentanyl to reach its peak effect.
采用概率单位分析来预测在插入喉罩气道时，与2.5mg.kg⁻¹丙泊酚联合使用的芬太尼的最佳剂量。总共招募了21名男性和54名女性健康中国患者，年龄在18 - 63岁之间，因小手术需要麻醉。他们被分为五组之一：安慰剂组、0.5、1.0、1.5和2.0μg.kg⁻¹。给药90秒后进行插入操作，并使用六类评分评估插入条件。仅能绘制吞咽和运动类别的剂量 - 反应曲线，且仅能确切预测半数有效量（ED₅₀）。为了在超过95%的患者中提供最佳条件，所需的芬太尼剂量远高于临床范围。1μg.kg⁻¹的标准芬太尼剂量与2.5mg.kg⁻¹丙泊酚联合使用时，在65%的病例中提供了最佳条件。90秒的时间可能不足以使芬太尼达到其峰值效应。
