Kujala Urho M, Kaprio Jaakko, Rose Richard J
Department of Health Sciences, University of Jyväskylä, Finland.
Addiction. 2007 Jul;102(7):1151-7. doi: 10.1111/j.1360-0443.2007.01858.x.
To control for familial confounds, we studied the association between adolescent physical activity and later smoking in twin siblings discordant for their baseline physical activity.
In this prospective population-based twin study, we asked whether persistent physical activity/inactivity in adolescence (assessed at 16, 17 and 18.5 years) predicted questionnaire-reported daily smoking at ages 22-27. Twins who, on the three baseline questionnaires, consistently reported frequent leisure physical activity (more than three times weekly) were classified as persistent exercisers, those who exercised less than three times monthly were called persistently inactive, others were occasional exercisers.
Finland.
A total of 4240 individuals, including 1870 twin pairs. Findings In analyses of individual twins, compared to persistent activity, persistent physical inactivity predicted increased risk of daily smoking (age- and sex-adjusted odds ratio 5.53, 95% confidence interval 3.88-7.88, P < 0.001). The risk remained elevated even after excluding all those who had smoked 50 cigarettes or more life-time at baseline and adjusted for educational level in adolescence. In within-pair analyses compared to the active members of discordant twin pairs, the physically inactive co-twins had increased risk of future daily smoking (sex-adjusted odds ratio 3.39, 95% confidence interval 1.56-7.39, P = 0.002).
Persistent physical inactivity in adolescence relates to adult smoking, even after familial factors are taken into account.
为控制家族性混杂因素，我们研究了双胞胎兄弟姐妹中，青少年身体活动与后期吸烟之间的关联，这些双胞胎在基线身体活动方面存在差异。
在这项基于人群的前瞻性双胞胎研究中，我们询问青少年时期（在16、17和18.5岁时评估）持续的身体活动/不活动是否能预测22 - 27岁时问卷报告的每日吸烟情况。在三份基线问卷中，持续报告频繁休闲身体活动（每周超过三次）的双胞胎被归类为持续锻炼者，每月锻炼少于三次的被称为持续不活动者，其他的为偶尔锻炼者。
芬兰。
总共4240人，包括1870对双胞胎。研究结果 在对个体双胞胎的分析中，与持续活动相比，持续身体不活动预示着每日吸烟风险增加（年龄和性别调整后的优势比为5.53，95%置信区间为3.88 - 7.88，P < 0.001）。即使排除了所有在基线时一生吸烟达50支或更多且对青少年教育水平进行调整后，该风险仍居高不下。在双胞胎对内分析中，与不一致双胞胎对中的活跃成员相比，身体不活动的同卵双胞胎未来每日吸烟风险增加（性别调整后的优势比为3.39，95%置信区间为1.56 - 7.39，P = 0.002）。
即使考虑了家族因素，青少年时期持续的身体不活动仍与成人吸烟有关。
