Venkatesan Narayanan, Punithavathi Durairaj, Babu Mary
Faculte de Medecine, UMR-7561, CNRS UHP, Vandoeuvre lès Nancy, France.
Adv Exp Med Biol. 2007;595:379-405. doi: 10.1007/978-0-387-46401-5_17.
The aim of this review has been to describe the current state of the therapeutic potential of curcumin in acute and chronic lung injuries. Occupational and environmental exposures to mineral dusts, airborne pollutants, cigarette smoke, chemotherapy, and radiotherapy injure the lungs, resulting in acute and chronic inflammatory lung diseases. Despite major advances in treating lung diseases, until now disease-modifying efficacy has not been demonstrated for any of the existing drugs. Current medical therapy offers only marginal benefit; therefore, there is an essential need to develop new drugs that might be of effective benefit in clinical settings. Over the years, there has been increasing evidence that curcumin, a phytochemical present in turmeric (Curcuma longa), has a wide spectrum of therapeutic properties and a remarkable range of protective effects in various diseases. Several experimental animal models have tested curcumin on lung fibrosis and these studies demonstrate that curcumin attenuates lung injury and fibrosis caused by radiation, chemotherapeutic drugs, and toxicants. The growing amount of data from pharmacological and animal studies also supports the notion that curcumin plays a protective role in chronic obstructive pulmonary disease, acute lung injury, acute respiratory distress syndrome, and allergic asthma, its therapeutic action being on the prevention or modulation of inflammation and oxidative stress. These findings give substance to the possibility of testing curcumin in patients with lung diseases.
本综述的目的是描述姜黄素在急性和慢性肺损伤中的治疗潜力现状。职业和环境中接触矿物粉尘、空气传播污染物、香烟烟雾、化疗和放疗会损伤肺部，导致急性和慢性炎症性肺病。尽管在肺病治疗方面取得了重大进展，但迄今为止，尚无任何现有药物被证明具有改善病情的疗效。目前的药物治疗仅能带来些许益处；因此，迫切需要开发可能在临床环境中产生有效益处的新药。多年来，越来越多的证据表明，姜黄素这种存在于姜黄（Curcuma longa）中的植物化学物质，具有广泛的治疗特性，在各种疾病中具有显著的保护作用。多个实验动物模型已对姜黄素在肺纤维化方面进行了测试，这些研究表明姜黄素可减轻由辐射、化疗药物和毒物引起的肺损伤和纤维化。来自药理学和动物研究的越来越多的数据也支持这样一种观点，即姜黄素在慢性阻塞性肺疾病、急性肺损伤、急性呼吸窘迫综合征和过敏性哮喘中发挥保护作用，其治疗作用在于预防或调节炎症和氧化应激。这些发现使在肺病患者中测试姜黄素成为可能。
