Han Jian Rong, Deng Bin, Sun Jing, Chen Chao Gang, Corkey Barbara E, Kirkland James L, Ma Jing, Guo Wen
Department of Medicine, Obesity Research Center, Boston University School of Medicine, Boston, MA 02118, USA.
Metabolism. 2007 Jul;56(7):985-91. doi: 10.1016/j.metabol.2007.03.005.
Prior studies of medium-chain triglyceride (MCT) suggest that MCT might be a useful tool for body fat mass management in obese nondiabetic humans. We now report a pilot study that tests if MCT is beneficial for moderately overweight subjects with type 2 diabetes mellitus. The study was conducted in a group of 40 free-living subjects in an urban area of China. The subjects were randomized into 2 test groups, with one given MCT and the other corn oil as control for long-chain triglycerides (LCTs). The test oil (18 g/d) was administered as part of daily food intake for 90 days. All subjects completed the study with self-reported full compliance. Body weight, waist circumference (WC), and serum samples were analyzed on days 0, 45, and 90. The MCT group showed an across-time reduction in body weight and WC, an increase in serum C-peptide concentration, a reduction in homeostasis model assessment of insulin resistance, and a decrease in serum cholesterol concentration (P < .05, repeated measures). No significant across-time difference for the above parameters was detected for the LCT group. These changes were associated with an involuntary reduction in energy intake in the MCT group (P < .05, repeated measures). A between-group comparison also shows reduced body weight, WC, and homeostasis model assessment of insulin resistance in the MCT group compared with the LCT group at the end of the study. Collectively, our results suggest a link between moderate consumption of MCT and improved risk factors in moderately overweight humans in a low-cost, free-living setting.
先前对中链甘油三酯（MCT）的研究表明，MCT可能是肥胖非糖尿病患者控制体脂的有效工具。我们现在报告一项初步研究，该研究测试了MCT对中度超重的2型糖尿病患者是否有益。该研究在中国一个城市地区的40名自由生活的受试者中进行。受试者被随机分为2个测试组，一组给予MCT，另一组给予玉米油作为长链甘油三酯（LCT）的对照。测试油（18克/天）作为日常食物摄入量的一部分，持续服用90天。所有受试者均报告完全依从并完成了研究。在第0、45和90天对体重、腰围（WC）和血清样本进行了分析。MCT组的体重和WC随时间下降，血清C肽浓度升高，胰岛素抵抗的稳态模型评估降低，血清胆固醇浓度降低（P<0.05，重复测量）。LCT组上述参数未检测到显著的随时间变化差异。这些变化与MCT组能量摄入的非自愿减少有关（P<0.05，重复测量）。组间比较还显示，在研究结束时，MCT组的体重、WC和胰岛素抵抗的稳态模型评估均低于LCT组。总体而言，我们的结果表明，在低成本、自由生活的环境中，适度食用MCT与中度超重人群的危险因素改善之间存在联系。
