Wolfs Claire A G, Dirksen Carmen D, Kessels Alfons, Willems Daniëlle C M, Verhey Frans R J, Severens Johan L
Department of Clinical Epidemiology and Medical Technology Assessment, Maastricht University Hospital, Maastricht, Netherlands.
Health Qual Life Outcomes. 2007 Jun 14;5:33. doi: 10.1186/1477-7525-5-33.
The EQ-5D is a reliable tool for measuring Health-Related Quality of Life (HRQoL). However, concern has been expressed that it may ignore elements of HRQoL, particularly cognition. In response to this concern, the EQ-5D has been extended with a cognitive dimension (EQ-5D+C). The aim of this study was to compare the performance of the EQ-5D and the EQ-5D+C in elderly patients with cognitive impairments by assessing their construct validity and responsiveness.
Data from the MEDICIE study (n = 196) were used, in which all questionnaires were rated by proxies.
Regarding construct validity, we found similar correlations between the EQ-5D and the Mini Mental State Examination (MMSE) and between the EQ-5D+C and the MMSE. Furthermore, both the EQ-5D and the EQ-5D+C were responsive to changes in the MMSE, with the EQ-5D performing slightly better.
We conclude that the EQ-5D performs well for evaluating HRQoL in a population with cognitive impairments. Based on the results of this explorative study, it does not seem necessary to adjust the current classification system by adding a cognitive dimension. However, in order to compare both instruments regarding utility values, it is necessary to develop a new scoring algorithm for the EQ-5D+C by conducting a general population study. Considering the explorative nature of this study, it is recommended that more aspects of the validity of both the EQ-5D and the EQ-5D+C are explored in patients with cognitive impairments using a more tailored study design.
EQ-5D是一种用于测量健康相关生活质量（HRQoL）的可靠工具。然而，有人担心它可能会忽略HRQoL的某些要素，尤其是认知方面。针对这一担忧，EQ-5D增加了一个认知维度（EQ-5D+C）。本研究的目的是通过评估老年认知障碍患者的结构效度和反应性，比较EQ-5D和EQ-5D+C的性能。
使用了MEDICIE研究（n = 196）的数据，其中所有问卷均由代理人进行评分。
关于结构效度，我们发现EQ-5D与简易精神状态检查表（MMSE）之间以及EQ-5D+C与MMSE之间的相关性相似。此外，EQ-5D和EQ-5D+C对MMSE的变化均有反应，EQ-5D的表现略好。
我们得出结论，EQ-5D在评估认知障碍人群的HRQoL方面表现良好。基于这项探索性研究的结果，似乎没有必要通过增加一个认知维度来调整当前的分类系统。然而，为了比较这两种工具的效用值，有必要通过开展一项普通人群研究来为EQ-5D+C开发一种新的评分算法。考虑到本研究的探索性质，建议使用更具针对性的研究设计，在认知障碍患者中探索EQ-5D和EQ-5D+C有效性的更多方面。
