Canseven Ayse G, Keskil Zuhal Aktuna, Keskil Semih, Seyhan Nesrin
Department of Biophysics, Gazi University Medical Faculty, and Gazi Non-Ionizing Radiation Protection Center, Ankara, Turkey.
Int J Radiat Biol. 2007 Apr;83(4):231-5. doi: 10.1080/09553000701206676.
To investigate whether pre- and post-drug magnetic field (MF) exposure of 50 Hz, 0.2 mT has any significant effect on pentylenetetrazol (PTZ)-induced seizures in mice.
MF was generated by a pair of Helmholtz coils. Seizures were induced by PTZ injection intraperitoneally (i.p.) at a dose of 60 mg/kg. A total of 48 locally bred adult female mice 25-35 g in weight were used. Latency to seizure, total seizure duration, and mortality were recorded for each mouse.
Neither pre- nor post-drug exposure to a 50 Hz, 0.2 mT MF was found to have any effect on PTZ-induced epileptic seizures or mortality rates in mice.
The present study failed to provide any support for a therapeutic potential of a 50 Hz, 0.2 mT MF for epilepsy.
研究50赫兹、0.2毫特斯拉的药物前后磁场（MF）暴露对戊四氮（PTZ）诱导的小鼠癫痫发作是否有显著影响。
MF由一对亥姆霍兹线圈产生。通过腹腔注射（i.p.）60毫克/千克剂量的PTZ诱导癫痫发作。总共使用了48只本地饲养的成年雌性小鼠，体重25 - 35克。记录每只小鼠的癫痫发作潜伏期、总癫痫发作持续时间和死亡率。
未发现药物前后暴露于50赫兹、0.2毫特斯拉的MF对PTZ诱导的小鼠癫痫发作或死亡率有任何影响。
本研究未能为50赫兹、0.2毫特斯拉的MF治疗癫痫的潜力提供任何支持。
