Park Won-Hee, Chae Young-Joo, Soh Kwang-Sup, Lee Byung-Cheon, Pyo Myoung-Yun
Pharmaceutical Analysis Team, Seoul Metropolitan Government Research Institute of Public Health & Environment, Seoul, Korea.
Electromagn Biol Med. 2012 Dec;31(4):293-8. doi: 10.3109/15368378.2012.662191. Epub 2012 Jun 7.
We investigated the comparative effects of 4 and 60 Hz magnetic fields on pentylenetetrazole (PTZ)-induced seizure in mice. For this study, we measured the latent time to seizure, seizure duration, and lethality induced by PTZ in mice exposed to 4 and 60 Hz magnetic fields (MF) for 30 min. Compared to sham-exposed controls, the latent time to tail twitching and seizure in the 4 Hz MF group was significantly decreased while the latent time to seizure in the 60 Hz MF group was significantly increased. The seizure duration in the 4 Hz MF group was significantly decreased while that in the 60 Hz MF group was significantly increased. More importantly, while the mice exposed to a 60 Hz MF experienced significantly increased lethality after seizure convulsion, those exposed to a 4 Hz MF showed no lethality, with a shortening of the duration of seizure. This beneficial effect of a 4 Hz MF on seizure has the same implication as the anti-oxidative effects of a 4 Hz MF observed in our previous work. The results of our current and previous works indicate that a 4 Hz MF may be used as a therapeutic physical agent for the treatment of oxidative stress-induced diseases, including seizure, with or without chemical drugs.
我们研究了4Hz和60Hz磁场对戊四氮（PTZ）诱导的小鼠癫痫发作的比较影响。在本研究中，我们测量了暴露于4Hz和60Hz磁场（MF）30分钟的小鼠中PTZ诱导的癫痫发作潜伏期、发作持续时间和致死率。与假暴露对照组相比，4Hz MF组尾巴抽搐和癫痫发作的潜伏期显著缩短，而60Hz MF组癫痫发作的潜伏期显著延长。4Hz MF组的发作持续时间显著缩短，而60Hz MF组的发作持续时间显著延长。更重要的是，暴露于60Hz MF的小鼠在癫痫惊厥后致死率显著增加，而暴露于4Hz MF的小鼠未出现致死率，且癫痫发作持续时间缩短。4Hz MF对癫痫发作的这种有益作用与我们之前工作中观察到的4Hz MF的抗氧化作用具有相同的意义。我们目前和之前工作的结果表明，4Hz MF可作为一种治疗性物理因子，用于治疗包括癫痫发作在内的氧化应激诱导的疾病，无论是否使用化学药物。
