Amonsin A, Songserm T, Chutinimitkul S, Jam-On R, Sae-Heng N, Pariyothorn N, Payungporn S, Theamboonlers A, Poovorawan Y
Faculty of Veterinary Science, Chulalongkorn University, Pathumwan, Bangkok, Thailand.
Arch Virol. 2007;152(10):1925-33. doi: 10.1007/s00705-007-1010-5. Epub 2007 Jun 18.
Complete genome sequences of H5N1 viruses derived from a domestic cat "A/Cat/Thailand/KU-02/04" and dog "A/Dog/Thailand/KU-08/04" were comprehensively analyzed and compared with H5N1 isolates obtained during the 2004 and 2005 outbreaks. Phylogenetic analysis of both cat and dog viruses revealed that they are closely related to the H5N1 viruses recovered from avian influenza outbreaks of the same period. Genetic analysis of 8 viral gene segments showed some evidence of virulence in mammalian species. In summary, the H5N1 viruses that infected a domestic cat and dog are highly pathogenic avian influenza viruses that are virulent in mammalian species, potentially indicating transmission of H5N1 viruses from domestic animals to humans.
对源自家猫“A/Cat/Thailand/KU - 02/04”和狗“A/Dog/Thailand/KU - 08/04”的H5N1病毒的全基因组序列进行了全面分析，并与2004年和2005年疫情期间获得的H5N1分离株进行了比较。对猫和狗病毒的系统发育分析表明，它们与同期从禽流感疫情中分离出的H5N1病毒密切相关。对8个病毒基因片段的遗传分析显示出在哺乳动物物种中具有一定毒力的证据。总之，感染家猫和狗的H5N1病毒是高致病性禽流感病毒，对哺乳动物具有毒性，这可能表明H5N1病毒可从家畜传播给人类。
