父母吸烟对新生儿可替宁水平的影响。
Effect of parental smoking on cotinine levels in newborns.
作者信息
Joseph D V, Jackson J A, Westaway J, Taub N A, Petersen S A, Wailoo M P
机构信息
University of Leicester, Leicester Royal Infirmary, Leicester LE2 7LX, UK.
出版信息
Arch Dis Child Fetal Neonatal Ed. 2007 Nov;92(6):F484-8. doi: 10.1136/adc.2006.108506. Epub 2007 Jun 19.
BACKGROUND
Smoking is a major risk factor for cot death. Many infants smoke passively as a result of parental smoking. This paper reports on infants exposed to a smoking environment and how they accumulate metabolites of cigarette smoke, such as cotinine, which may be physiologically harmful.
AIM
To assess cotinine levels in infants of smoking parents.
METHOD
Cotinine excretion in urine was assessed in 104 infants, of whom 71 had smoking parents and 33 had non-smoking parents. All cotinine levels were measured at approximately 12 weeks of age. The subjects were selected from a database of infants in developmental physiological studies which assessed the impact of various factors on early postnatal development.
RESULTS
On average babies with at least one parent who was a current cigarette smoker excreted 5.58 (95% CI 3.4 to 9.5) times as much cotinine in the urine as did the babies of non-smoking parents. Maternal smoking was the largest contributing factor. Co-sleeping (p = 0.037) and the minimum room temperature (p = 0.028) were significant contributory factors.
CONCLUSION
Infants from smoking households accumulate cotinine, a metabolite of nicotine, which may have a detrimental effect on the cardiorespiratory system.
背景
吸烟是婴儿猝死综合征的主要风险因素。许多婴儿因父母吸烟而被动吸烟。本文报告了暴露于吸烟环境中的婴儿以及他们如何积累香烟烟雾的代谢产物，如可替宁，这可能对生理有害。
目的
评估父母吸烟的婴儿体内可替宁水平。
方法
对104名婴儿的尿液中可替宁排泄情况进行评估，其中71名婴儿的父母吸烟，33名婴儿的父母不吸烟。所有可替宁水平均在约12周龄时测量。这些受试者选自发育生理学研究的婴儿数据库，该研究评估了各种因素对出生后早期发育的影响。
结果
平均而言，父母中至少有一方为当前吸烟者的婴儿尿液中可替宁的排泄量是非吸烟父母婴儿的5.58倍（95%可信区间3.4至9.5）。母亲吸烟是最大的影响因素。同睡（p = 0.037）和最低室温（p = 0.028）是显著的影响因素。
结论
来自吸烟家庭的婴儿会积累可替宁，一种尼古丁的代谢产物，这可能对心肺系统产生有害影响。
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