Zhuang Li-Xing, Zhao Ming-Hua, Yang Jun-Jun, Deng Qian-Ping
Department of Acu-moxibustion, First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou 510405, China.
Zhen Ci Yan Jiu. 2007 Feb;32(1):53-7.
To compare the therapeutic effects of medicinal vesiculation performed in the dog-days and ordinary-days, as well as "Xin"-days and "Geng"-days in the treatment of bronchial asthma.
A total of 162 bronchial asthma patients were divided into ordinary-days group (n = 80) and dog-days group (n = 82) according to the time sequence. Plasters made up of Gansui (Radix Euphorbiae Kansui), Baijiezi (Semen Sinapis Albae), Mahuang (Herba Ephedrae), Xixin (Herba Asari), etc. were applied to Feishu (BL 13), Fengmen (BL 12), Dingchuan (EX-B 1), Pishu (BL 20) Shenshu (BL 23), etc. during ordinary days (spring, summer, autumn and winter), dog days (the 1st-, 2nd- and 3rd-10 day periods of the hot season) for each group, once every 10 days and with 3 times being a therapeutic course. After a course of treatment, the curative effect was assessed. Before and 5 days after the treatment, venous blood samples were collected for detecting serum immunoglobulin E (IgE), lymphocyte transformation rate (LTR) and the number of eosinophile granulocytes (Eos) separately. In addition, other 80 asthma patients were treated during "Geng"-days ( (n = 42) and "Xin"-days (n = 38) separately with the same methods mentioned above.
After one course of treatment, or the 82 and 80 cases in dog-days group and ordinary-days groups, 35 (43%) and 31(39%) experienced marked improvement in clinical symptoms, 41 (50%) and 37 (46%) had an improvement, 6 (7%) and 12 (15%) failed, with the effective rates being 93% and 85% respectively. After the treatment, serum IgE and Eos count of the two groups decreased significantly (P < 0.01, 0.05), and LTR of the two groups increased evidently (P < 0.01). No significant differences were found between two groups in the therapeutic effect and the 3 biochemical indexes. In other 80 asthma patients, of the 42 and 38 cases in "Geng"-days group and "Xin"-days group, 23 (54.76%) and 17 (44.74%) experienced marked improvement in their symptoms, 17 (40.47%) and 19 (50.00%) had an improvement, 2 (4.76%) and 2 (5.26%) failed, with the effective rates being 95.23% and 94.74% separately. No significant difference was found between two groups in the therapeutic effect (P > 0.05).
Medicinal vesiculation therapy can effectively improve asthma patients' clinical symptoms, lower serum IgE and Eos count and raise LTR whenever performed in the ordinary days, dog days, "Xin" days or "Geng" days. Thus, this therapy is applicable all year round.
比较三伏天与非三伏天、辛日与庚日药物发泡疗法治疗支气管哮喘的疗效。
将162例支气管哮喘患者按时间顺序分为非三伏天组（n = 80）和三伏天组（n = 82）。两组分别于非三伏天（春、夏、秋、冬）、三伏天（炎热季节的头伏、中伏、末伏），采用由甘遂、白芥子、麻黄、细辛等制成的药膏贴敷于肺俞（BL 13）、风门（BL 12）、定喘（EX - B 1）、脾俞（BL 20）、肾俞（BL 23）等穴位，每10天贴敷1次，3次为1个疗程。治疗1个疗程后评定疗效。治疗前及治疗后5天分别采集静脉血，检测血清免疫球蛋白E（IgE）、淋巴细胞转化率（LTR）及嗜酸性粒细胞（Eos）数量。另外，将80例哮喘患者分别于庚日（n = 42）和辛日（n = 38）采用上述相同方法治疗。
三伏天组82例、非三伏天组80例患者经1个疗程治疗后，临床症状显著改善者分别为35例（43%）和31例（39%），改善者分别为41例（50%）和37例（46%），无效者分别为6例（7%）和12例（15%），有效率分别为93%和85%。治疗后两组血清IgE及Eos计数均显著降低（P < 0.01，0.05），LTR均明显升高（P < 0.01）。两组疗效及3项生化指标比较差异无统计学意义。另外80例哮喘患者中，庚日组42例、辛日组38例患者经治疗后，症状显著改善者分别为23例（54.76%）和17例（44.74%），改善者分别为17例（40.47%）和19例（50.00%），无效者分别为2例（4.76%）和2例（5.26%），有效率分别为95.23%和94.74%。两组疗效比较差异无统计学意义（P > 0.05）。
药物发泡疗法无论在非三伏天、三伏天、辛日或庚日进行，均可有效改善哮喘患者的临床症状，降低血清IgE及Eos计数，提高LTR。因此，该疗法全年均可应用。
